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Superoxide dismutase activity during on-pump, off-pump and on-pump without cardiac arrest CABG procedures.

Aleksander Sienczewski, Tomasz Poprawka, Marek Bartkowiak, Henryk Wysocki*, Ryszard Kalawski, Tomasz Siminiak**
Szpital im. J. Strusia, Poznań; * PSK 2, Poznań; ** Szpital Wojewódzki, Poznań


Background. Free oxygen radicals, including the superoxide anion (O2-), released by activated neutrophils (PMN) are known to be important in the pathogenesis of myocardial ischaemia followed by reperfusion. The plasma level of a free-radical scavenger, superoxide dismutase (SOD) has been reported to correlate with myocardial salvage after ischaemia.

The aim of this study was to evaluate the influence of global and partial myocardial ischaemia during coronary artery bypass (CABG) procedures for SOD activity.

Methods. 53 patients (aged 42-78 mean 52) subjected to CABG were divided into three groups. Group I: 16 patients, on-pump procedure with aortal clamping. Group II: 18 patients, on-pump procedure anastomoses were constructed on beating heart without cardiac arrest (sustained partial coronary perfusion). Group III: 19 patients, off-pump procedure. Samples for analysis were taken from peripheral vein before (A) installation of cardio-pulmonary bypass (CBP) in group I and II and before first anastomosis in group III. Second set of samples (B) was obtained after aortal declamping in group I or after last anastomosis in groups II and III. SOD activity was measured spectrophotometricaly.

Results. Results are expressed in kU/l as mean!SEM. *p


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