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DNA structure from A to Z — biological implications

of structural diversity of DNA

Małgorzata Bukowiecka-Matusiak\ Lucyna A. Wozniak¹'²'^M

¹ Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences; Department of Bioorganic Chemistry, 112 Sienkiewicza Str.,

90-363 Łódź, Poland

^Medical University, 7/9 Żeligowskiego Str., 90-752 Łódź, Poland

^se-mail: [e-mail], [e-mail]

Key words: DNA, conformation, structure, duplex, triplex, tetraplex

ABSTRACT

Deoxyribonucleic acid (DNA) is a biopolymer of nucleotidet., usually adopting a double-stranded helical form in cells, with complementary base pairing holding the two strands together. The most stable is B-DNA conformation, although numerous other double helical structures can occur under specific conditions (A-DNA, Z-DNA, P-DNA). The existence of mułtiple-stranded (triplex, tetraplex) forms in vivo and their biological function in cells arę subject of intensive studies.

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