nlReader2
Pathophysiological Effects of Vibrio cholerae and Enterotoxigenic Escherichia coli and Their Exotoxins on Eucaryotic Cells
KAREN L. RICHARDS and STEVEN D. DOUGLAS
Departmenis of Microbiology and Medicine, University of Minnesota Medical School. Minneapolis, Minnesota 55455
INTRODUCTION............................................................................................592
PATHOPHYSIOLOGY...................................................................................593
Eliology................................................................................................................593
Factors in Pathogenesis.......................................................................................593
Gcnctic and Physiological Basis for Toxin Production.......................................593
THE TOXINS...................................................................................................594
Structure...............................................................................................................594
Antigenic Rclatcdncss of Toxin$.........................................................................594
Binding Sitc.........................................................................................................595
Action of Toxins on Adenylate Cyclase..............................................................596
Solubilized Adenylate Cyclase and Toxins.........................................................597
Cofactors Rcquircd forToxin Activity................................................................597
Involvement of Guanosine 5-Monophosphate (GMP).......................................597
Effect of Increased Intracellular Cyclic Adenosine 3’.5’-Monophosphate..........598
Variability in Activation of Adenylate Cyclase...................................................598
Similarities to Glycoprotcin Hormoncs and Othcr Bacterial Toxins...................598
Vaccines and Immunity.......................................................................................599
ENTEROTOXINS IN IN VIVO SYSTEMS...................................................600
Wholc-Animal Models........................................................................................600
llcal Loop Assay..................................................................................................600
Skin Permeability Assay......................................................................................601
ENTEROTOXINS IN IN VITRO SYSTEMS.................................................601
Erythrocyte Ghosts...............................................................................................601
Adrcnal Cells.......................................................................................................602
Isolated Fat Cells.................................................................................................603
Lymphocyte and Lymphoid Celi Lines and the Immune Response....................603
Fibroblasts............................................................................................................604
Othcr Celi Systems..............................................................................................604
DISCUSSION...................................................................................................605
CONCLUSIONS..............................................................................................606
LITERATURĘ CITED.....................................................................................606
Wyszukiwarka
Podobne podstrony:
Łojkowska E., Lewosz J., 1984. The effect of wound healing and of certain Chemicals on electrolyte rFor these reasons, thc present Siudy was aimed at understanding thc effect of decodcr accuracy and k148 Banks, L. M., B. Lees, J. E. MacSweeney et J. C. Stevenson (1994). Effect of degenerative spinałPertanika 14(1). 53-57 (1991)Effects of Ascorbyl Palmitate and Silicone on Frying Performance of PalSlajd33 2 Akademia medycyny i pięknaElektroporacja Fig. 3. Effect of pulse voltage and time on fenta2.1 Introduction This chapter will give you a brief orientation of the nodes and their functions inBadania molekularne iThe classification of lung cancers and their degree of malignancy by FTIR, PCA-Agata Paluch, Anna RodzeńForms of motivating employees and their usage in contemporaryVIII. Drozdowska Danuta, Szerszenowicz Jakub, Semi-Automatic Synthesis of Distamycin Analogues and TS5002127 82VI. Survey of the finds and their contribution to our knowledge of the economic basis ofwięcej podobnych podstron