F00574 011 f002

F00574 011 f002



Cłuiescent

Restriction point (regulated by growth factors)

Antibiotics and alkylating agents (act on entire cycle)

Terminal differentiation Apoptosis

Mitotic spindle poisons)

G1 checkpoint for Damaged DNA Rb blocks

p53->CDKs btocked

G2 checkpoint for DNAdamage Further grovyth

DNA replication or DNA rePair incomplete

Topoisomerase inhibitors


Mitosis

Propbase-»telophase Nuclear and cellular dwision Terminal differentiation Apoptosis

© Elsevier. Boon et al.: Davidson's Principles and Practice of Medicine 20e - www.studentconsult.com


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