3582428612

SEMESTER SYLLABUS FOR V SEM. TO VIII SEM

T351 Pharmaceutical Technology I. (Theory)

(3hr$/week) 45 Hours Section-I

Sr. No.	TOPICS	Hrs.
1	Preformulation: Objective. study of physico Chemical properties of drug like physical form, particie size, shape, density. wetting. dielectric constant, solubility, PKa, partition coefficient, dissolution on an organoleptic property and their effect on formulation, stability and bioavailability.	04
2	Tablets: - Formulation development: types of tablets. properties of drugs such as compressibility. flowability, dose, stability. site of drug release & absorption. additives & factors affecting their selection. Formulation and manufacture of tablets and quality contro! of tablets. Introduction to advance granulation techniques: Extrusion-spheronization & pelletization & spherical crystallization. fluid bed granulation. Problems in tableting & remedies there of.	07
3	Coating of Tablets: - Types (sugar, film & press coating). Materiał used & processed employed for each, coating eguipments induding diff. Types of coating pans. fluid bed coating. Evaluation of coated tablets & packaging of coated tablets.	04
4	Hard Gelatin & Soft Gelatin Capsules :• Introduction, Shell excipients. Mfg. of shells. properties of raw matenals. environmental Controls. evaluation. filling equipments for hard Soft gelatin capsules. Processing. I.P.O.C., evaluation of finished capsules & offiaal standards.	04
5	Semisolid Dosage Forms: • Classification. dermatological & transdermal preparations-Emulsion. Gel & Ointment Preparations. mechanism of drug penetration. transdermal penetration enhancer-Probable Mechanism & Examples. Ointments: bases, formulation factors. Mfg. processes & eguipments. packaging & evaluation. guality control.	04

Section-ll

Sr. No	TOPICS	Hrs.
6	Packaging science: Primary and secondary packaging materiał* component of packages and various accessories, packing materiał selection their evaluation, closure, pilfer proof and tamperproof packaging .child resistant packaging, blister and strip packing.	05
7	Disperse Systems: • Introduction. theories of emulsifications and suspensions-DLVO Theory.
	types of additives used in formulations. vehicles. stabilizers. preservatives wetting agents. emulsifying agents. colors and flavors. HLB values and its determination. Manufactunng. packaging and evaluation of emulsions and suspensions. Introduction to micro and multiple emulsions.	07
8	Suppositories: Ideał requirements of bases. manufacturing procedurę, packaging and
	evaluation.	04
9	Pharmaceutical Aerosols: Definition. propellants, generał formulation. manufacturing and
	packaging methods, pharmaceutical application and Evaluation.	04
10	Pilot Plant Scalę Up: Groups responsibilities-Fadlities*example of scalę up	02

Total Hrs. - 45

Books Recommended:

1.    Leon Lachman et al. Theory & practice of Industrial pharmacy, Lea & Febiger Varghese Publishing house, Mumbai.

2.    H.A. Lieberman & Leon Lachman Pharmaceutical Dosage Forms: Tablet Vol. 1, 2, 3. Marcel Dekker Series.

3.    G.S. Banker & C.T. Rhodes. Modern Pharmaceutics. Marcel Dekker Senes.

4.    H. C. Ansel- P ceutical dosage forms & drug delivery systems. B.l. Waverly Pvt.ltd, New Delhi.

5.    Alfanso R. Gennaro- Remingtons Pharmaceutical Sciences. Mack Publishing Company, Easton Pennsylvania.

6.    EARawling - Bentleys T.B. of pharmaceutics. Bailliere Tindall {London} & AJI India Traveller Book Seller Delhi.