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Impact of cellular senescence on organismal aging and age-related diseases

Anna Bielak-Żmijewska , Wioleta Grabowska, Dorota Przybylska

Laboralory of the Molecular Bases of Aging, Nencki Institute of Experimental Biology, 3 Pasteura St., 02-093 Warsaw, Poland ^: e-mail: [e-mail]

Key words: c ellular senescence, aging, age-related diseases, CVD ABSTRACT

Development of the civilization and medicine enables an even longer lifespan of people. To modulate the aging process it is necessary to discover its molecular mechanism and its causes. It has been known for almost 60 years that cells undergo senescence. A lot of markers of senescence have been described to distinguish senescent cells. Every year we can observe an inerease in the number of data, supporting the thesis that the reason for aging of the whole oiganism is cellular senescence. We age because cells building tissues and oigans undergo senescence. It is also believed that cellular senescence can inerease the frequency of age-related diseases. The role of cellular senescence strictly depends on the age of the individual. In young ones it is essential for protection against cancer and tissue regeneration. In old ones it causes tissues and organs dysfunctions and leads to age-related diseases. Slowing down aging could precent age-related diseases and this seems to be morę promising than curing them. To enrich our knowledge conceming aging it is important to understand signaling pathways leading to senescence. Recently a new role of cellular senescence has been discovered, namely during embryogenesis. This observation is very surpris-ing and shows a new face of cellular senescence. It is possible that, similarly to the previously described role of apoptosis in embryogenesis, senescence is indispensable for proper organogenesis. Cellular senescence seems to be the universal and fundamental process, the role of which changes during the lifespan.

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