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common in babie* aflcctcd by Iow growth. The powerful inhibitmu factor on fungol growih was cfcmonstiatcd m vitro (a : http://www.ief.org).

i.*/ immurwt Awwtr Activation

Dhcnn.n-Duthille et ai. (19) ahowed (hal U is unphcated in the lymphocyics CD4 reguła non. esśer.tial u> conirol dtscasc li i* Icnown thal LF is directiy linked :o immunc response but studies in this way have to bc decpened to understand the linking mccłianisma LF and itnmune sy*te*n (a hnp://wwiv lcf.org).

3.5.    Anti-InJlamtMiory ActMty

Chi.<snv et Yakubovsknya (13J have proposcd on ointmcnf contawing LF as active prtnciple against rhumntotd arthntis. LF modulatcs the infiamroatcfy process, mor* especially by corly stimnlating the cxcrction of cytokincs from monocytcs. and by regutoting rhe prolif-eration ond diffcrcntiation of immuni2ed cells. Somc of thosc activitics orc caplaincd by the affinity of LF' for somc hpopolysacchamlcs (LPS) peesent at the surtacc of monocytcs. Ali together. iIkjsc obscrvatioos strongly suggested chat 1 S is one of tlić main mołcculcs ablc to niodulatc the inflammatory resjxsrise JS).

Fillebeen c/ o/. (30] studied the LF canying thrxługh the hematomaunge barrier in in flammafnry concłituins !>ie LF cnrTicd by activatcd cnpillary endothchsl cells m bovme brain was mereosed The LF was rccovercd undamaged on the ahluminal side ol the cells, suggesting that mcrcascd accumulation of LF cotild occur in physiopatholcigica! condttions

3.6.    AnaJgcsic Aclwity

The ‘Nuclcar Kcccptcc Ugand’ socicty is dcvcloping mcdicamcnt on LF basis This team wwkiiti; *^] K*wsw*ki (Lifwti) in purtnmhip with Agcnmx Inc. (Tcxcn) ia beginning clinical rrials oo ircatment against pain. Sornt trials condoctcd by dtts company and Tottori Knivcr-sity (Southern Japan) oti rats have shown that LF w** an efficiciit analgcsic, with a similar eftkieticy as morphine in local applicaliofi, the LF bewg ikgraikd in the słomach. This company wanted (u devd<ip the u*c of LI in a mcdir.tmcnl foc pari>m1np.Mhy and hope lo Coopera te with agro-lbod industnes <b: ww^.biotcchnłca.a^so.fruploc^bjotechnicn'' Hv0O6.pdf)

3.7.    Anti-Oxicfa:ivc Aciwity

The anti-oxśdativc activit:cs of LF depend on its obility to bind ferrous ions (37|. The anti-oxidativc activity of LF is strongly higher thar. compounds uscd gcncrnlly in pharmacy (Tablc 7) (13).

Bdizi era!. (6] showed tliat LF inłiibited free radicals morccffcctivcly thon liistidin and ounnitol. Włtctt I.F of human milk was added at suspension of cggś Itpoprotcin yełk with rodatnm Ci intcnsity of Fe2* induction of chcmilumtneioent was 37% lowcr. At 100% of iron samrnticin thcir antioxidant piopcrties decrea^c 15.4%aixl intcnsity of chcmilununcs* cent wa$ docrcasc 25.7^/u comparcd to control. Also, Bclm »v al [7) otiseived tlial coni-pound of LI from humnn milk dunug inuihiliun in a physmlogical likc model showg spontancous de^aminntion.

3.8.    Anti-Carciwt%cncc Actwify

Chissov et al. | J3. J4] prepared a prodoct on LF basis to usc in oropharyngal zonę Mer a

rh^n>r.thr*r*nv Thł* I V Jlhl/* fn /V>nlpihul«> %n »vrAl»f.*łor;An nww on»t ^InUr r*iff-rv*n#t'o