Citrate
Isocitrate
Succinyl-CoA
PYRUVATE
Glucose-6-P
Fructose-6-P
Fructose-1,6-bis-P
3-P-Glyceraldehyde
Glycerone-3-P
1,3-bis-P-Glycerate
3-P-Glycerate
2-P-Glycerate
ATP
ATP
ADP
ADP
2Pi
NADH+2H
2NAD
+
+
2ADP
2H2O
2ADP
2ATP
(Di-OH-acetone- P)
P-enolpyruvate
PYRUVATE
GLYCOLYSIS & TCA CYCLE -
EQUATIONS
Oxaloacetate
Fumarate
Malate
Succinate
GLUCOSE
2
ATP
2
ACETYL-CoA
2HSCoA
2HSCoA
2NAD+
2NADH+2H+
2NADH+2H+
2NADH+2H+
2NADH+2H+
2H2O
2CO2
2CO2
2CO2
2GTP
2GDP
2H2O
2NAD+
2HSCoA
2NAD+
2NAD+
2Pi
HOCH
2
---C---C---C---C--CHO
H H OH H
OH OH H OH
P-OCH
2
P-OCH
2
P-OCH
2
P-OCH
2
P-OCH
2
---C---C---C---C--CHO
OH OH H OH
H H OH H
---C---C---C---CO--CH
2
OH
OH OH H
H H OH
---C---C---C---CO--CH
2
OP
OH OH H
H H OH
COCH
2
OH
CH(OH)CHO
P-OCH
2
P
CH(OH)COO-
CH
2
=C(O-P) COO
_
P-OCH
2
CH(O- )COO
P
_
CH
3
COCOO
_
P -OCH
2
CH(OH)COO
_
CH
2
COO-
C(OH)COO-
CH
2
COO-
CH(OH)COO-
CHCOO-
CH
2
COO-
-OOCCOCH
2
CH
2
COO-
-OOCCH
2
CH
2
COO-
-OOCCH
2
CH
2
CO.SCoA
-OOCCH=CHCOO-
-OOCCH(OH)CH
2
COO-
-OOCCOCH
2
COO-
CH
3
CO.SCoA
c
2001IUBMB
G
L
Y
C
O
L
Y
S
I
S
T
C
A
C
Y
C
L
E
PYRUVATE
DEHYDROGENASE
2UQH2
2UQ
2-Oxoglutarate
6CO
2
+
10NADH +10H+ + 2UQH2
+2ATP+2GTP
Anaerobic Oxidation of Glucose to CO2 and Reduced Co-factors
C
6
H
12
O
6
+ 10NAD+ + 2UQ + 2ADP +2Pi + 2GDP+2Pi + 4H
2
O
Oxidation of Glucose to Pyruvate
C
6
H
12
O
6
+ 2ADP + 2Pi + 2NAD+
2CH
3
COCOO- +
2ATP
+
2NADH + 2H+
+ 2H2O
Pyruvate to Acetyl-CoA
2CH
3
COCOO- + 2HSCoA + 2NAD+
2CH
3
CO.SCoA +
2NADH + 2H+
+ 2CO
2
Acetyl-CoA to CO
2
and Reduced Co-factors
2CH
3
COCOO- + 6NAD+ + 2UQ + 2GDP + 2Pi + 4H
2
O
4CO
2
+ 2HSCoA +
6NADH + 6H+ + 2UQH
2
+
2GTP