Citrate

Isocitrate

Succinyl-CoA

PYRUVATE

Glucose-6-P

Fructose-6-P

Fructose-1,6-bis-P

3-P-Glyceraldehyde

Glycerone-3-P

1,3-bis-P-Glycerate

3-P-Glycerate

2-P-Glycerate

ATP

ATP

ADP

ADP

2Pi

NADH+2H

2NAD

+

+

2ADP

2H2O

2ADP

2ATP

(Di-OH-acetone- P)

P-enolpyruvate

PYRUVATE

GLYCOLYSIS & TCA CYCLE -

EQUATIONS

Oxaloacetate

Fumarate

Malate

Succinate

GLUCOSE

2

ATP

2

ACETYL-CoA

2HSCoA

2HSCoA

2NAD+

2NADH+2H+

2NADH+2H+

2NADH+2H+

2NADH+2H+

2H2O

2CO2

2CO2

2CO2

2GTP

2GDP

2H2O

2NAD+

2HSCoA

2NAD+

2NAD+

2Pi

HOCH

2

---C---C---C---C--CHO

H H OH H

OH OH H OH

P-OCH

2

P-OCH

2

P-OCH

2

P-OCH

2

P-OCH

2

---C---C---C---C--CHO

OH OH H OH

H H OH H

---C---C---C---CO--CH

2

OH

OH OH H

H H OH

---C---C---C---CO--CH

2

OP

OH OH H

H H OH

COCH

2

OH

CH(OH)CHO

P-OCH

2

P

CH(OH)COO-

CH

2

=C(O-P) COO

_

P-OCH

2

CH(O- )COO

P

_

CH

3

COCOO

_

P -OCH

2

CH(OH)COO

_

CH

2

COO-

C(OH)COO-

CH

2

COO-

CH(OH)COO-

CHCOO-

CH

2

COO-

-OOCCOCH

2

CH

2

COO-

-OOCCH

2

CH

2

COO-

-OOCCH

2

CH

2

CO.SCoA

-OOCCH=CHCOO-

-OOCCH(OH)CH

2

COO-

-OOCCOCH

2

COO-

CH

3

CO.SCoA

c

2001IUBMB

G

L

Y

C

O

L

Y

S

I

S

T

C

A

C

Y

C

L

E

PYRUVATE

DEHYDROGENASE

2UQH2

2UQ

2-Oxoglutarate

6CO

2

+

10NADH +10H+ + 2UQH2

+2ATP+2GTP

Anaerobic Oxidation of Glucose to CO2 and Reduced Co-factors

C

6

H

12

O

6

+ 10NAD+ + 2UQ + 2ADP +2Pi + 2GDP+2Pi + 4H

2

O

Oxidation of Glucose to Pyruvate

C

6

H

12

O

6

+ 2ADP + 2Pi + 2NAD+

2CH

3

COCOO- +

2ATP

+

2NADH + 2H+

+ 2H2O

Pyruvate to Acetyl-CoA

2CH

3

COCOO- + 2HSCoA + 2NAD+

2CH

3

CO.SCoA +

2NADH + 2H+

+ 2CO

2

Acetyl-CoA to CO

2

and Reduced Co-factors

2CH

3

COCOO- + 6NAD+ + 2UQ + 2GDP + 2Pi + 4H

2

O

4CO

2

+ 2HSCoA +

6NADH + 6H+ + 2UQH

2

+

2GTP