replikacja DNA

DMA REPLICATION

Replicationcomplex (Prokaryotes) 5 '

lagging strand

r

DMA ligase

RNase H / poi I

Remoral of RN A primer Gap-filling

Joining of Okazaki fragment

DNA polymerase III holoenzyme

poi III core

leading strand

5 ' 3 '

poi III core

DNA polymerase III holoenzyme

pnmase

3 ' 5 '

		0
		e
		a.
		V& T
clamp		8'
P	X	8

V 6 complex

DrtaB

DnaG

SSB

DKApofrmeneel DNA. Łgćce

RNaseH

Dpol

Lig

Replicationcomplex (Eukaryotes)

lagging strand

5 '

3 '

Joining of Okazaki fragment

RNase HI or Dna2

Removal of RN A primer Gap-filling

DNApolymerase 6

EN W    complex

leading strand

5 ' 3 '

clamp

clamp loader

DNA polymerase a- primese complex

al	a2	Pril	Pri2
DNA pok	tmerase 6 complex
61	62	63	84
DNA polymerase e complex
cl	c2	c3	z4

RPA

DNApolymerase e complex

3 ' 5 '

MCM complex (helicase)

Mcm2	Mcm3
Mcm4	Mcm5
Mcm6	Mcm?

RPA1

RPA2M

RPA3

clamp

clamp loader

PCNA		RFC1	RFC2/4	RFC3/5
helicase		RNaseHI
Dna2		RNseeH2A	m&łZB	HIksHEC

03030 04/16/03

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