Slajd30 2

Akademia medycyny i piękna

Ultradźwięki - kawitacja

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Fig. 6. Temperaturę mcreases, as a function of tune, induced by sonophoresis at three different mtensities (10. 25, 70%), corre-spondmg to 4.5, 8.1 and 15 W cm” . Eaeli data point represents tlie mean±S.D. of $ix measurements.

Time (mlnutes)

(A) Macro Level

1 2

(—	^ c	J	(
'—	3
	—	)	c_

(B) Micro Level

** Fig. 2. At the macro level (A), phonophoresis is thought to enhance drug penetration through the stratum comeum transcellularly (Iin a process tcrmed acoustic streaming, or through increased porę size (2), in a process termed ultrasonic srirring. At the micro level (B), an alteration in lipid bilayer lipids results in enhanccd drug diffusion through pores in the celi membranę.

* Gustayo Merino et al. Frequency and thermal effiects on the enhancement of transdermal transport by sonophoresis Journal of Controlled Release 88 (2003) 85-94