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Patofizjologia chorób wątroby Zapalenia wątroby

	HAV	HBV	HCV	HDV	HEV
modę oftransmis-sion	fecal orał	sexual contact, bloodto blood, perinatal	sexual contact, bloodto blood, perinatal	can cause infection only inthe presence of HBV, transmitted similarto HBV	fecal orał
Infectious-ness	two weeks before onset of illness, not infectious after first week of jaundice	before symptoms appear and for 4-6 months after acute illness. May be chronic carriers who are always infectious to others.	1-2 weeks before symptoms appear, throughoutclinical course. Indefmitely in chronic carriers	throughoutall phases of active infection	not known, probably similarto HAV
Lab tests	Anti-HAV Ig M (current infection), Anti-HAV IgG (past resolved infection)	HbsAg (current or chronic inf.), HBeAg (marker for incr.activity), Anti-HBc (marker for inf. at some time), AntiHBe (marker for decr. inf.), AntiHBs (marker for immunity, produced in response to vaccine)	Anti-HCV (marker for infection)	AntiHDV IgM (current inf.) Anti HDV IgG (past infection)	serological tests under development
Remarks	complications rare, importance ofgood handwashi ng	up to 10% become chronic carriers, and at risk forcirrhosis, liver cancer	50% chronic carriers, at risk forcirrhosis, chronic liver disease, cancer	chronic carriers of HBV at risk throughout carrierstate	few cases seen in US, most in Asia, Africa and Mexico

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