41 2

IL-1/IL-6/TNF-a

&

urn:

5 £

Liver

Bonę marrow endothelium

Hypothalamus

Fat.muscle

Dendritic cells

Acute-phase

proteins

(C-reactive

protein,

mannose-

bindinglectin)

Neutrophil

mobilization

Increased

body

temperaturę

Protein and energy mobilization to allow increased body temperaturę

TNF-a stimulates migration to lymph nodes and maturation

** *-7				'-r T-* *-7
Ns/ Activationof complement Opsonization		s/ Phagocytosis		N/ v Decreased viral and bacterial replication Increased antigen Processing Increased specificimmune response		Initiation of adaptive immune response

Figur* 2-46 lmmunobioiogy.6/t.(< GtrUnd Scicnc* 200$)