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FIGURĘ 12.50 Microtubule motor proteins Kinesin and dynein move in opposite directions along micro-tubules, toward the plus and minus ends, respectively. Kinesin consists of two heavy chains (wound around each other in a coiled-coil structure) and two light chains. The globular head domains of the heavy chains bind mi-crotubules and are the motor domains of the molecule. Dynein consists of two or three heavy chains (two are shown here) in association with multiple light and intermediate chains. The globular head domains of the heavy chains are the motor domains. The models shown are based on X-ray crystallography data (After R. D. Vale, 2003. Celi 112: 467).

- end

+ end

Dynein

Kinesin