IMGP3175

Xeroderma pigmentosum

The basie defect in XP is in nucleotide eicision repair (NER), leading to deficient repair of DNA damaged by Uv radiation. This extensively studied process consists of the removal and the repla cement of damaged DNA with new DNA.

Twotypes ofNERexist: global genome (GG-NER) and transcription coupled (TC-NER). The last decade has scen the cloning of the key ełements of NER, and the process has been reconstituted in vitro.