14 Leukocyte adhesion deficfency (LAD) type I.
S resufis from a defect In the synthesis of fucosylated Carbohydrates. o *s cnaracfensed by defects in neutrophil rołłmg and extravasation £ feads to to neutrophil adherence to endotheliał ttssue d causes recurrent bacterial and fungal infcctions
15. Cetfu lar imm unity inciudes ad of the fol łowi ng except
ą actrvated macrophages killing phagocytosed bactena b. CD8 T cells inducing apoptosis using Fas-FasL binding. ę. complement-mediated lysis of bactehal cells d MHC-resbicted cytotoxic T cells killing virus-infected cells ę NK cells performing natural killing of tumor cells.
16. CTL binding and destruction of target cells depends on
a. a co-stimulatory signal from the target celi.
b. antigen presentation on the surface of the target celi. ę. lack of a negative signal from MHC to prevent cytotoxicity. d presence of virus proteins in the membranę of the target celi. e secretion of cytokines by the infected celi to attract CTL.
17. CTL use perforin to
a. activate the classical complement cascade to łyse the target.
b. allow granzymes to enter the target celi and initiate apoptosis. ę. promote target celi lysis by macrophages.
d. stimulate the target cells to express Fas on their membranes
e. substitute for C9 in the alternative complement pathway.
a. IL-1 and IL-6.
b. IL-2 and IFNy.
c. IL-4 and IL-5.
a. nitric oxide.
b. oxygen radicals.
c. perforins.
** tp. ię> ity