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INFLAMMATORY MEDIATORS: TNF-ALFA AND TRYPTASE IN PATIENTS WITH SEVERE CARDIOMYOPATHY
Mirosław Mussur1, Katarzyna Piestrzeniewicz1, Marzanna Zielińska1, Janusz Kawiński1, Janina Wyczółkowska2, Barbara Kolago2, Halina Bolińska1, Janusz Zasłonka1
1 Instytut Kardiologii AM w Łodzi, Łódź; 2 Zakład Amin Biogennych PAN, Łódź

Backgrounds & aims: Cardiomyopathy is a serious disease in which the heart muscle becomes inflammed and does not work as well as it should. Proinflammatory molecules derived from mononuclear phagocytes and cardiac mast cells may have deleterious effects on cardiac muscle function. We evaluated mast cell protease-tryptase, TNF-α, and troponin T release in patients with severe idiopathic dilated and hypertrophic cardiomyopathies as well as secondary ischemic cardiomyopathy and small EF (<25%) (n=79), and healthy subjects (n=12).
Methods and results: In all the patients of control group and in 39 patients with cardiomyopathy (49%) troponin T plasma levels were normal values (<0.01 ng/ml). TNF-α levels, when measured by
ELISA method, were higher in cardiomyopathy group than in healthy subjects (from 3.7+1.2 to 11.77+6.37 vs. 2.41+0.85 pg/ml, respectively). Moreover, our results show that in the advanced phase of dilated and ischemic cardiomyopathy resulting in death take place significant plasma increase of all three studied parameters, i.e. tryptase, TNF-α, and troponin T.
Conclusions: Increased plasma levels of mast cell protease-tryptase and TNF-α are prodrome signs of poor prognosis in preterminal patients suffering dilated or ischemic cardiomyopathy. The results indicate that cardiac contractile protein breakdown take place.



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