1437212091

I Ogólnopolska Konferencja Naukowa Krimed

Metody badawcze w kryminalistyce i medycynie sądowej Wystąpienia Gości Honorowych

The use of tandem mass spectrometry (ms/ms) in modern forensic toxicology

Mass spectrometry is undoubtedly one of the fastest growing and most widely used detection methods in various fields of science. Due to the possibility of combining it with other techniąues and number of parameters allows for a fuli characterize the sample in terms of ąuality and ąuantity. Providing a single analytical process to identify several parameters is particularly important in forensic toxicological analysis.

Great advances in mass spectrometry relates primarily tandem systems, particularly systems of serially connected ąuadrupole analyzers. This solution allows for selecting interesting ion, carrying out a controlled decomposition into fragments and analysis of ions resulting from fragmentation. With the help of tandem mass spectrometers, it is possible to study fragmentation reaction of selected ions and on this basis conclusions to be drawn about the structure of the analysis compounds and determining ion pairs for the quantitative determination even in highly complex mixtures, eg. blood or urine. In this way we gain significant acceleration analysis, morę efficient filtering matrix and conseąuently obtain greater specificity and reliability of the results. These Solutions provide the ability to perform testing for existing and new substances under the control of the Act on prevention of drug abuse.

The aim of the presentation is to review the latest developments and opportunities of tandem mass spectrometry in clinical forensic toxicological for example, a comprehensive analysis of synthetic cannabinoids using the GC-MS/MS and rapid screening analysis of antipsychotics by LC-MS/MS.

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