IMG54 (4)

7. LFA-1 is a(n)

a.    co-receptor on T cells.

b.    co-stimulatory molecule on APC. ę. cytokine receptor on APC.

d.    integrin on T cells.

e.    vascular addressin on HEV.

8. Which informatlon does not concern E-selectin:

a.    E-selectin expression is largely restricted to activated endothelial cells.

b.    expression of E-selectin on vascular endothelium is induced by LPS and IL-1.

c.    E-selectin ligand-1 (ESL-1) is the major ligand for E-selectin.

d.    E-selectin binds to P-selectin ligand-1 (PSGL-1) with a very high affinity.

9. Select the false answer: a. only activated integrins bind ligands.

£. stimulus that activates the integrin may be provided by chemokines

c.    activationof neutrophils to endothelial cells is mediated by the interaction of p integrins with selectins expressed by endothelial cells.

d.    adhesive interaction mediated by pi integrins can contribute to leukocyte rolling

10. The effector molecules of cytotoxic T cells do NOT include a. Fas.

'^granzyme s.

c.    IFNy.

d.    perforin. ę. TNFp.

11. Interferons

a ąctivate B cells to make virus-specific antibodies. b. are Th2 cytokines.

c^are virus proteins that interfere with activation of cytotoxic T cells.

d.    interfere with virus entry into host cells.

e.    inhibit virus replication by infected cells.

12. IL-1 is produced by macrophages and acts on the hypothalamus to induce fever. This is an ex< of_cytokine action.

lig autocrine. b. endocrine.

"S^paracrine.

d.    pleiotropic.

e.    synergistic.

13. CD40 on macrophages binding to CD40L on Th1 cells signals the macrophages to a die.

b.    ||| cytoplasmic viruses.

c.    phagocytose the Th1 cells.

respond to IFNy by expressing morę membranę MHC.

§ secrete IL-2.