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PENTOXIFYLLINE DECREASES ROS GENERATION IN PATIENTS WITH TRANSIENT MYOCARDIAL ISCHAEMIA
J. Kowalski. Z. Baj, J. Błaszczyk, J. Kędziora
Military Medical Academy, Łódź, Poland


We estimated the effect of pentoxifylline (PTX) on reactive oxygen species (ROS) generation by unprimed neutrophils and those primed with tumour necrosis factor (TNF-α) in patients with transient myocardial ischaemia (exercise test and PTCA procedure). Chemiluminescence of unprimed as well as primed with TNF-α neutrophils was measured. Forty two patients with stable angina were examined in whom exercise test was applied on cycloergometer and, after three days, PTCA was performed. The patients were randomly allotted into two groups. The study group consisted of 28 patients who were administered PTX orally (3 x 400 mg/day) and the control group of 14 patients with no drug administration. Our study has been approved by the local Ethics Committee. Blood samples were collected for examination from cubital vein just before and 10 min after the exercise test or PTCA procedure. Chemiluminescence of formyl-Met-Leu-Phe (fMLP) stimulated neutrophils was measured. Transient myocardial ischaemia caused the increase in ROS generation by neutrophils in the control group. In the study group PTX diminished ROS generation by unprimed neutrophils stimulated by fMLP before and after the exercise test and PTCA procedure, in comparison to the control group. Moreover, PTX diminished stimulated by fMLP Chemiluminescence of TNF-α primed neutrophils before the exercise test and PTCA procedure. No TNF-α effect on neutrophils observed after transient myocardial ischaemia caused by exercise test or PTCA procedure can point to endogenous release of this cytokine during transient myocardial ischaemia.










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