Paracetamol overdose > 75 mg/kg body weight
Measure paracetamol level in blood and plot on curve
High-risk linę
Enzyme induction, e.ęj. those on anticonvulsant drugs, chrome alcohol excess Glutathione depletion, e.g. malnutrition, eating disorders
4 12
Time sińce ingestion (hrs)
If thc paracetamol level is abovc the treatment linę, start N-acctylcysteinc
15 mins
4 hrs
150 mg/kg in 200 ml 0.9% salinę
50 mg/kg in 500 ml 0.9% salinę
100 mg/kg in 1 litre 0.9% salinę
20 hrs
Check renal w and liver function tests and
prothrombin ratio or INR
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