100722

Acetaminophen - poisoning

o Patients with malnutrition, AIDS, chronic ethanol abuse, or anorexia nervosa may be at increased risk for morbidity because of deficient glutathione Stores and inadequate detoxification of NAPQI. Patients with enhanced ability to make NAPQI due to induction of the P450 system, specifically cyp2El, may be at increased risk of morbidity. The agents that induce this enzyme activity include rifampin, phenobarbital, isoniazid, phenytoin, carbamazepine, or chronic ethanol ingestion.