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cysteinę protease mechanism

Catalytic mechanism of cysteinę proteinases

Acylation

Deacylation

Peptide substrate

HĆ-R_n

Cys—s —C—NH—CH----

Tetrahedral transition State

A

! "

c—OH

II

N-ter peptide released

o

V

V

C-ter peptide released

HC— r

i n

cys_s— c

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(F rom http ://delphi .phy s ,univ-tour s. fr/Proly sis/) http://cgat.ukm.my/protease/cysteinemech.html