Slajd31 (16)

Slajd31 (16)



RETINOBLASTOMA

Retinoblastoma occurs in early chiidhood and affectsabout 1 child in 20,000. The tumor develops from the immature retina - the part of the eye responsible for detecting light and color. There are both heneditary and non-hereditary forms of retinoblastoma. In the hereditary form, multiple tumors are found in both eyes, while in the non-hereditary form oniy one eye is effected and by only one tumor. In the hereditary form, a gene calied Rb is iost from chromosome 13. Since the absence of Rb seemed to be iinked to retinoblastoma, it has been suggested that the role of Rb in normal cells is to suppress tumor formation. Rb is found in all cells of the body, where under normal conditions it acts as a brake on the celi division cycle by preventing certain regulatory proteins from triggering DNA replication. If Rb is missing, a celi can replicate itself over and over in an uncontrolled manner, resulting in tumor formation. Untreated, retinoblastoma is almost uniformly fatal, but with early diagnosis and modern methods of treatment the survival ratę is over 90%. Since the Rb gene is found in all celi types, studying the molecular mechanism of tumor suppression by Rb will give insight into the progression of many types ofcancer, not just retinoblastoma.


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