1

Acetokinaza -tiokinaza octanu

ATP + CH₃COCT + CoASH ► CH₃—- C — SCoA + AMP + PP,

O

Tiolaza acctoacctylo-CoA O    O

CH₃—C —SCoA + CH₃—C—SCoA-► CH. —C —CH —C —SCoA + CoA-

HMG Co syntaza (3-hydroksy-3-metyloglutarylo Co: acctoacctylo CoAliaza)

C - SCoA

n ?^{H2 0}

ch₃

o

+ CH₃ —c —SCoA

+h₂o

Acetoacetyl CoA    Acetyl CoA

Cl RE 17.31

pGCoA synthase rcaction.

Rcduktaza HMG CoA

^SCoA

c

ch₂

HO — C—CH₃ + CoA

CH₂

COOH HMG CoA

CH₂OH

CH₂

-► HO —C—CH₃ + CoA CH₂

coo-

Mevalonate

2NADP’

C — SCoA CH₂

H0-C-CH₃ 2NADPH ♦ 2H*

CH₂

I

coo-

HMG CoA

RE 17.32

CoA rcductasc rcaction.