IMGP3214

| Fanconi Anaemia

hyprrpigmcntation nnd/or cafć au hit spots In 80%

(60%),

particularly radius axis defects (tbwnt or nypoplasric thumb or radius...)

(In ronfrast

with most otłjcr chromosomc instabilify syndTomcs)^

mcan agc of onśct of anemia: 8 yrs; diagnosis madę before onset of haematologic manifestations in only 30%

rvnal anomaiks,

hypogonadbm, menlal impairment, BH defrefs, and perhaps diabetes mdlilus. also occur in 10 to 30% of