IMGP5555
Neurofibromatosis type 1
• Clinicai Diagnosis
• Si.v or morę cafć au lait maculcs ovcr 5 mm in grcatcst diameterin prepubertal individuals and over 15 mm in greatcst dianie ter in postpubcrtal individuals
• Two or morę neurofibromas of any type or one plexifbrm neurofibrnma
• Frcckling in the axillary or inguinal regions
• Optic glioma
• Two or mnrc Lisch nodules (iris hamartomas)
A distinctitc osscous lesion such as sphenoid dysplasia or thinning of long bonę cortcx with or without pscudarthrnsis A flrsl-dcgrcc rclativc (pa rent, sib, or ofTspring) with NF1 as defined by the ahovc critcria
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