• Neurofibromas may affccf virtually any organ in thc body. Discrctc cutancous and subcutancous neurofibromas may develop at any firnie in life, bul they arc infrcqucnt bcforc pubcrty. The total number of neurofibromas scen in adults with NF1 varics from a few to hundreds or cvcn thousands.
Additionai ćutancous and subcutancous neurofibromas ton lin uc to dcvclop throughout life, although thc ratę of appearance may vary greatly from year to year.
Many nomen experience a rapid inerease in the number and sizc of neurofibromas during prcgnancy