Antidiarrheals


Diarrhoea

Diarrhoea involves either an increase in fluid secretion into the gut, a reduction of fluid absorption from the gut or an increase in motility


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Antidiarrheals


So, how do antimotility agents work?

First, we need to know about gut motility ...


• Two types of movement: - Peristaltic

• moves food forward


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- Segmental • Mixing

• Controlled by parasympathetics


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Lactase Deficiency... One Cause of Diarrhea


•    Deficiency of lactase at brush border

•    Increased lactose provides carbon for bacteria

•    Presents as bloating, crampy pain, osmotic diarrhea


Enzymes


Effect of Parasympathetic Activity on Gut Smooth Muscle

• Certain cells generate slow wave pacemaker potentials

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• This is increased by ACh

Force

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