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Table 3

Inducers of apoplosis

Physiologic activators	Chemicals	Biological factors	Toxins	Therapcutic agenta
TNF famiiy	Free radicals	Viral infcction	Ethanol	Glucocorticoid
Fas Ugand	Glutamatc	HIV	Af)atoxin	Chemotherapeutic drugs:
TNF	ASHe	Baculovirus	Retinoic acid	cisplatin
TGF-0 .CairaoduJin CaJcium Trophić factor withdrawal Glubóse Growth factors IL-2,-3,-10,-13 TGF/J Ncurotrophic factors Hormones IL-lfi converting enzyme Tissue transgJutamjnase Loss of matm attachmcnt	Hydrogen peroxyde	Cytotoxic T ceils Cytokines TNF-a TGF-/3 Hypertherrnia Extentcd cuiture in vitro Hcat shock protein	/J-amyloid peptide	doxorubicin bleomycinc cytosine arabinoside methotrexatc vincristine nitrogen mustard 7 radiation UV radiation Ca²⁺ ionophores Digoxyn RU 486 Prostaglandin E2

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