• Epidemiology
o Incidence: 4-6 per 100,000 in US and Europę o 50-60% of ON patients ultimately develop MS ■ 75% of women, 35% of men > 15% of patients with normal MR o 20-50% of ON patients have brain foci at presentaton o 15-25% of MS patient initialiy present with ON o 70-90% of MS patients develop ON at some point