DSC02168 (2)

Sieć cytokin zaangażowana w patogenezę rzs

Rheumafołd factor andotherigtoantibotfes I

I Interleukin- 4

IntfrWiUfł- 4 Interleukin- 10/ | Interleukin- 6 I Ptasma | I Interleukin- lol ■ crl    ł    i.    ^M~"

Th2

Macrophage

B celi

Interferony Interferony Interleukin-12    /

\ _/

CD4+T celi _

Synovium

CD6»

T

JCD1 li rCD69

Osteoaast

TNF-a.

Ł Interleukin-1 amkI Interleukin- 61

Chondrocyte)

» r r

Productlon of metalloproteinases and other effector molecules

Migration of polymorphonuclear cells EM

a

907-916.