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•^liich ol (lic fołlowing pairs of dnigs cannot bc uscd to (rcal bronchial astlunn7 (A) fonnotcrol — budcsonide ^^^noinctazonc - rauilidinc (Q fonnotcrol — (lulicasone propionntc (D) salincterol - budcsonide (E) saJntclerol - inomctazoite

31. Bcnzodiaiepincs:

A

, X'^v

(A) enliance GABA-ergic Iransraissioo (D) arc uscd in (lic Ucatmcnl of cpilcpsy \(C)/Ue loxic drugs (Iow Uierapeulic index) (D) increase lotal duntioo of sleep ^{E)'producc ainncsia ,i . •»/    •_:j

32. In aculc ankiety States. a rapid ocuci of therapeulic action will be obtained aAcr ireaUnenl wilh: i(Żv^ buspiron (B)^mproplon .(C^sulpirid /(DJ^iaicpam (ifE^n

i

i

Dircctions: Find approprialc lcllcied sutcmenis for numbcrcd ilcms relaied (o drugs uscd in Ucaimenl of Parkinson discase:

Dircctiom: Forach numbcrcd hem. sclect Ihc ONE Ictlcrcd option Ifcil is mosl doscly associaicd willi ii. Each Iciicrcd opi may bc sclcded oncc. morc Uian once, or not al all (qucslions 58 - 70)

(A) fludrocortisonc (B) corlisol    • (C) preduison (D) becloiucUusone (E) bcUmcUiasonc

58.    Endogenous substance Uut causes cali retenlion and buflalo hump in palients wilh Cushiog*s syndrome.

59.    Glucocorticoid wilh vc/y Iow mineralocorticoid adivity and vcry higli lopicai activiiy: uscd for dermatologie condiuons

6*

(D) colchicine

33.    L-DOPA

i

34.    Broinocripline

[K) D|, D] and Dj rcccplor agonisl (B) only 1% of (his dnig givcn o rally rcaches CNS (C) D₂ agonisl and D| partial antagonist (D) anlicholincrgic agent (E) a« adrcncrgic antagonist

(A) mdhotrexate    (B) peniciliaminę    (C) iniliximab

60.    Anti-rlieumalic drug e0cdivc also in llic inflammatory bowel discase.

61.    A slow acling anli-rhcuniatic drug tiul is ęytóloxić; also used in leukemia.

| I

(D) physosligminc

(A) piloenrpine

(B) succinylcholine (C) alracunum

(E) sulfacalajine

E) ncostigtninc

Dircciions: Coimcci ihc lislcd bel o w medianisins of aciions willi (lic proper anliscizurc agcnls:

35.    GABA polciilialion

36.    Na-clianncl błock

CA) pbcnytoin (B) gabapenlin (Q lamouiginc (D) valproic acid (E) clhosuximidc

62.    Indirccl-aciitig chólinomimclic; poor lipid soltibilily*. uscd in llic ircalitićiK of niyastlicnig

63.    Depolariiing ncuromuscular blocking drug. Gfb

Dircctions: ln (his scction (qucsiioiu 37 - 57) dccidc if ihc fołlowing siatemcnts abou( drugs arc TRUE (A) or FALSE (D).

—

W Zafirlukast anii-asiluiulic aciion: reduaś tlić aclivily of cyclooxygcnascF F"

38. Sumairiptan mli-migraine adion: aniagonizes 5-HTj jonolropic receptor, p f • y^Ll -39. Aiiiicholincsicrasc drugs arc vexy eflbcliye in ovcrconurtg Ihc blocking aciion of dcpęlarising blocking drugs.1 40. Atropinę Uierapy in Ihc elderly nuy bc hazardbus bccausc urinary rclcniion may bc prccipilatcd by atropinę inj • ⁴1- Au adequate supply of vitarnin B12 is requircd for folie acid uulisaiion. \

42.    Himdin cdmplcxcs willi aniilhrotnbin 111 (AT 111) and acceleralcs ihc aciion of AT l^F-

43.    Drugs arc^uinly trans po Ocd across biological barriers by special carricr trans poru -y

44.    Marked lachycardia and fluid retenlion arc conipensaiory responses usually scen willi strong vasodilators.T

45.    Gcmfibrosil inlubits lipoproicin lipascf

46.    The major toxicity of (lic HMG-CoA rcductasc inhibilors is lissuc damage wilh rcsulling cievalion of enzymes of livcr and

inuscle.^ f    l    ^

47.    Poiency »s dciennined inainly by (be affinicy of Uie rcccplor for Ihc dmg^Tw^A^^

48.    Arypical aniipsycliolics arc much morę eflcctivc in irealmenl of negaiivc sympioins of sdiizoplircnia iliau Uie old ones.

49.    Ali catcdtolamincs show posluve Łootropic adion on llic licartX

50.    Calcium clianncl blockers di lale nuinly arterieC\~

51.    Loop diuretics (eg furosemide) have yenodiblor adion. f

52.    VerapamiFis e(Teaivńnd uve (n venlricular arrhylhinia.ę

53.    Jl.adrcnergic blockers are veiy uscfiil and eflicadous drugs in the ircainient of acuie licart failure. p.

54.    Tlie use of ACE inhibilors is conlraindicaled in pregnnnt woiiicn.^*

55.    Paracctamol is a uschli anlipyrelic and analgesic in cltildrcn."^”

56.    ACE-inliibilors are uscd in cardiac failure, bccausc of dirod posilive i no tropie adion on llie licart/|~

' 57. Propofol may bc uscd for day—case surgay.^j *T

(A) erythropoietin (B) aprolinin

64.    Uscd in the trcatincnl ofheparin ovcrdosc.

65.    Orał anticoagulant.

if

(Q warfarin

iWT

D) clopidogrcl

i M

E) protaminę

I.v0^c

ęjr*

.((B) lopcramid^ (Q naloxone

(A) na!lrcxone

Purc agonisl of opioid rcceplcrr, uscd in syinplomalic irratniciit of dianliea

2s- 67. Partial agonisl of opioid receptors; U-nuiy cause lachycardia

68. Opioid receptor antagonist; uiay be used orally

(D) pelidine

(E) pcntazocinc

A-

6 PN

7-

(A) plienylepltrine (B) oxyme(azoline (C) norepinephrine

69.    Agonisl of a₂ rcceplorr. il causes vasodila(ion and.bradycardia.--

70.    Agonisl of a, adrencrgic rcceplors; i( causes uasocońslriclion and il is uscd only lopically.

donidine

;pro

O

(E) prazosinc

-51