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Gór induces type-I interferon secretion m infected cells.

In order to deveIop oncolytic virotherapy as an effective and safe treatment for cancer, healthy cells should ideally be able to protect themselves against infection while cancer cells should be sensitive to viral lysis. We therefore tested the capacity of G mutants to induce type-I interferon secretion in L929 cells following infection at MOIs of 0.1 or 20 (Figurę 4). Mutants Gs, Gsr and Gó did not induce significantly higher IFN secretion than wild-type VSV at either MOIs. However, at an MOI of 0.1, mutant Gór

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