k
Eticnnc MC. Pisot X. FonnentoJL, Bcnsadoun RJ. Fonncnto P. Dassonville O. Francoual M. PoLssonnct G. Foninna X. Schneider M, Dcinard F and Milano G (1999) A mullifactorial approach iiKluding (uinour.il epidcminl growih faelor receptor, p53, thymidylate symhasc and dihydropyrimidine dehydrogennse to prediet treatment ouicoinc in head and neck cunccr patients rccciving 5-fluoroutacil. Br J Cancer 79: 1864-1869
Ewen MF. and Miller SJ (1996) p53 and iranstalioiuil control. Biochim Biophys Acta 1242.181-184
Fisher TC. Milncr AE. Grcgory CD. Jackman AL. Ahctnc GW. 1 lartlcy JA. Divc C and Hickman JA (1993) txl-2 modulation of apoptosis induced by anlicanccr drugs: rcsistancc to thymidylate stress is independent of classical rcslstancc pathways. Cancer-Rcs 53: 3321-3326
Fu L, Mindcu MD and Bcnchimol S (1996) Tmnslational regulation of hunian p53 gcnc c.\pression. EM BO J 15: 1392-4401 Gorgoulis VG. Zacharatos PV. Manolis F. Ikonomopoulos JA, Damalas A.
Laniprinopoulos C. Rassidakis GZ. Zoumpourlis V. Kotsinas A. Rassidakis AN. Halazonctis ‘ID and Kittas C (1998) Effects of p53 mutnnts derised front lungcarcinomas on the p53rcspon$ivc element (p53RE) of the MDM2 gcnc. Br J Ca,ICC, 77: 374-384
Guillouf C. Grana X. ScKakumaran M. Dc Luca A. Giordano A. Hoffman B and Licbennann DA (1995) Disscction of the gcnctic progmms of p53-mcdiatcd GI growih arrest and apoptosis: blocking p53-ituluccd apoptosis unmasks G1 arrest. Blootl 85: 2691-2698
Gussow D. Rein R. Ginjaar i. Hochstcnhach F. Sccmann G. Kottman A and Ploegh HL (1987) The human beta 2-microglobulin gcnc. Primary slructurc and definition of the trnnscriptional unit. J Inmuaiol 139: 3132 3138 Harris CC (1996) Slructurc and function of the p53 tumor suppiessor gcnc: clucs for rational canccr thempeutie strategies. J Natl Cancer Insi 88: 1442-1455 Hudson JM. Frude R and Bar Fli M (1995) Wild-type p53 regulatcs ils own transcriplion in n ccll-typc sjxcilic manner. DNA Ccii Biol 14: 759-766 Huibrcgisc JM. SchclTncr M and Howley PM (1993) Clomng and exprcssion of the cDNA for F6-AP. a protein tliot mediates the intcrnclion of the haman papillomavirus F6 oncoprotcin willi p53. Mol Celi Biol 13: 775- 784 Kastan MB. Onyckwcre O. Sidnmsky D. Vogelstciu B and Craig RW (1991)
Panicipation of p53 protein in the cellular response to DNA damage. Canccr Rcs 51: 6304 6311
Kirihara Y. Yamamolo W. Togę T and Nishiyama M (1999) Dihydropyrimidine dchydrogenasc. imiltidrug icsisianee-associatcd protein, and thymidylate synthasc gene exj)rcssion lcvcls ean prediet 5-fluorounicil rcsistancc in human gastrointeslinal canccr cclls. Im .1 Orno! 14: 551-556 Koshiji M. Adachi Y. Takctani S. Takcuchi K. Ilioki K and Ikchara S (1997)
Mechanisms undcrlying apoptosis induced by combination of 5-lluorouracil and interferon-gamma. Biochem Biophys Rcs Coinmnn 240: 376-381.
Kren BT. Tremblcy JH and Stcer CJ (1996) Altcrations in mRNA stability during rat livcr regeneration. Am .1 Physial 270: G763-777 Kuhbutat Mil. Jones SN and Ybusden KH (1997) Regulation of p53 stability by Mdtn2. Naimr 387: 299-303
Kucrbitz SJ. Plunkclt BS. Walsh WV and Kastan MB (1992) Wild-ly|X p53 is a ccii cyclc chcckpoinl determinant following irradiation. Proc Nail Acatl Sci USA 89: 7491-7495
Loignon M. Fetni U. Gordon AJ and Drobctsky FA (1997) A p53-indepcndcnt pathway for induction of p2l waflcipl and concomitant G1 arrest in UV-imuliatcd human skin fibroblasUc. Canccr Rcs 57: 3390-3394 Lowc SW, Ruley HF. Jacks T and Housman DF (1993) p53-dc|xndent apoptosis modulates the cylotoxicity of anlicanccr agents. Cdi 74; 957-967 Macleod KF, Sherry N. Hannon Ci. Beach D. TokinoT. Kin/lci K. Vogc|stein B and Jacks T (1995) p53-dc|xiulcni and independent cxpression of p21 during ocli growtli. dilTcicntiation. and DNA damage. Genes Dcc 9:935-944 Massimi P and Banks L (1997) Reprcssion of p53 iranscr'iplional aclivily by the HPV E7 proteins. Vbvlogy 227: 255-259 Matlashcwski GJ. Tuck S. Pitn D. Umili P. Schneider J and Crawford LV (1987) Primary straciurc polymorphism at amino acid residuc 72 of human p53. Mol Ccii Biol 7: 961-963
Moll IJM. Ostcrmcycr AG. Haladay R. Winkficld B. Frazicr M and Zanibclti G (1996) Cytoplasmic sc(|uestration of wild-type p53 protein impairs the Gl chcckpoint after DNA damage. Mol Cdi Biol 16: 1126-1137 Momnnd J. Zambctti GP. Olson DC. Gcorgc D and Lcvinc AJ (1992) The nulm-2 oneogene prodncl lorms a complcx willi the p53 protein and inhibits |i53-mediated traiisactivation. Celi 69: 1237-1245
Mosner J. MunimenbraucrT, Bauer C. Sczakiel G. Grox.se Fand Dcppcrt W (1995) Negative feedback regulation of wild-type p53 biosynthesis. EMBOJ 14: 4442-4449
Nabeya Y. Loganzo F, Jr.. Maślak P. l.ai L. de Oliveira AR. Schwartz. GK.
Blundell ML. Altorki NK. Kclsen DP and Albino AP (1995) The mutaiional status of p53 protein in gastric and csophageal adcnocarcinoma celi lines prediets scnsitivity to chemoihcrapeutic agents. Im J Canccr 64: 37 46
Nita ME. Nagawa H. Tominaga O. Tsuno N. Fujii S. Sasaki S. Fu CG. Takenouc T. Tsurtto T and Muto T (1998</) 5-l luorouracil induccs apoptosis in hunian colon canccr celi lines wilh modulation of Bcl-2 Family proteins. Br J Canccr 78: 986-992
Nita ME. Tominaga O. Nagawa H, Tsuruo T and Muto T (19980)
Dihydropyrimidine dchydrogenasc but not thymidylate symhase cxpression is associated with rcsistance to 5-fluorouracil in colorectal canccr. Hcjmtogastrocnterolof’)- 45: 2117-2122
0'Connor PM. Jackman J. Jondle D. Bhatia K. Magrath I and Kołm KW (1993)
Role of tbc p53 tumor suppressor gcnc in ccii cyclc arrest and radiosensitisity of Burkitfs lymphoinn celi lines. Canccr Rcs 53: 4776-4780 Oltvai ZN. Milliman CL and Korsincyer SJ (1993) Bcl-2 hctcrodimcrizcs in vivo with a conscrved homolog. Bax. that accelcratcs progranuncd ccii dcath. Celi 74: 609-619
Orcn M (1994) Rclatiouship of p53 to the comrol of apoptotic ccii dcath. Seinin Canccr Biol 5:221-227
Ory K. Lcgros Y. Auguin C and Soussi T (1994) Analysis of the most reprcscntative iuni0Ur-dcrivcd p53 mutnnts rcvcals that changcs in protein conformation nre not corrclaicd willi loss of (rnnsactivation or inhibition of ccii prolifcrntion.
EM BO J 13: 3496 -3504
Palmcr DG. Paraskcvn C and Williams AC (1997) Modulation of p53 exprcssion in cultuicd colonie ndenoma ccii lines by the naturally occurring lumena] factors butyratc and dcoxycholate. Im J Cunccr 73: 702-706 Peters GJ. van der Will CL. van Triest B. Codacci-Pisanclli G, Johnston 1X3, van Grocningcn CJ and Pincdo HM (1995) Thymidylate symhasc and dmg rcsistancc. Em J Canccr 31 A: 1299 1305 Pincdo HM and Peters GF (1988) Fluorouracil: biochcmisiry and pharmacology.
J Clin Oncol 6: 1653-1664
Reed JC (1994) Bcl-2 and tlić regulation of ptograinincd ccii dcath. J Celi Biol 124: 1-6
Schcffner M. Wcrncss BA. Huibregtsc JM. Lcvine AJ and Howley PM (1990) The E6 oncoprotcin cucoded by human papillomavirus typcs 16 and 18 promotes the degrndation of p53. Celi 63: 1129-1136 Selvakumaian M. Lin HK. MiyashitaT. Wang HG. Krajewski S, Reed JC, Hoffman B and Licbcrmann D (1994) Immcdiaic cai ly up-rcgulnlion of bax cxprcssion by p53 but not TGF beta I: a pnradigm for dislinct apoptotic pathways. Oneogene9: 1791-1798
Sinumian PL, Grillot DA and Nuncz G (1997) Bcl-2 and Bc!-XL can differentially błock clrcmolhciapyinduccd ccii dcath. Blond 90: 1208-1216 Spcars CP. Gustavsson BG. Benic M. Frosing R. Bernstein L and llaycs AA (1988) Mechanisms of innatc rcsistancc to thymidylate symhasc inhibition after 5-fluorouracil. Canccr Rcs 48: 5894 5900 Stewart N. I licks GG. Paraskcvas F and Mowat M (1995) Evidcnce for a sccond ccii cyclc błock at G2/M by p53. Oneogene 10: 109- 115 Strobel T. Swanson L. Korsmcyer S and Cannistra SA (1996). BAX cnhanccs paclitaxcl-induced apoptosis through a p53-indcpcndcnt pathway. Proc Natl Acatl Sci USA 93; 14094-14099
Vogclstcin B and Kinzlcr KW (1992). p53 function and dysfunclion. Celi 70; 523-526
Wouters BG, Denko NC. Giaccia AJ and Brown JM (1999). A p53 and apoptotic-iiKlcpcndcnl role for p2l wal'1 m lumour response to radiation therapy. Oneogene 18: 6540-6545
Zaubcnnan A, Flusbcrg D. Haupt Y. Barak Y and Oren M (1995). A functional p53-rcsponsivc intronic promoter is contained within the human mdm2 gene. Nucicie Acids Rcs 23: 258-1-2592
Zhan Q. Fan S. Bae I. Guillouf C. Licbennann DA. 0‘Connor PM and Fornace AJ. Jr. (1994). Induction of bax by gcnotoxic stress in huinan cclls corrclatcs with normal p53 status and apoptosis (published erratum ap|xars in Oneogene 1995; 10(6): 1259) Oneogene 9: 3743-3751
/.hang Z.G. Hnrstrick A and Rustum YM (1992) Mechanisms of rcsistancc to fliioropyi iinidincs. Scmin Oncol 19: 4-9
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