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117

Age groups (mo)

Age groups (mo)

D

E

3 month

6 month

Leptin (ng/mL)

Figurę 3.1 : Impaired leptin production in Cd36-nuli mice

Plasma levels of leptin A) and plasma level of adiponectin B) were measured by ELISA in fasting 1-9 months-old WT and Cd36-nuli mice (n>5 per group). Leptin/adiponectin ratio was reduced in Cd36-nuli mice C). Conrelation between total body weight and plasma leptin level was observed in 3-6 month-old CY/36-null mice (n=9) D-E). Data represent mean ± SEM. Student t-test: *P<0.05, **P<0.01, ***P<0.001 compared to WT mice.