0407

A Voltages in axon [mV]

60-i

0-

/k	= - 77 mV		i
	V = - 65 mV	VNa = 50 mV	V = - 9 mV
	\V = - 54.4 mV
L	I^1 ° _:	1 2 Lj_1_	3

V - V, = - 59 mV m Na

4 Time [ms] 5

-20--40--60--80

Depolarization = 56 mV (Yoltage clamp)

V_m - V_K = 68 mV

v_m - V_L = 45 mV

B /_m [rrWcm²]

C /_K [mA/cm² 1.5-,

Potassium current i_Koutward

Measured afterchanging sodium concentrations to eguilibrium in clamp voltage (no sodium current)

D /„„[mA/cm²]

4 Time [ms] 5

1.0-0.5-0.0

0	0
-0	5 _
-1	0_
E ic	+ )
1	O-i
0	5-
0	0-

Sodium current inward /_Na= / - /_K

4 Time [ms] 5

Capacitive and leakage currents / + /_L outward

(Notę the different time scalęj

40

60

80 Time [fi s] 100