Mapa metaboliczna ENG (1)

INDOLGLYCEROL

PHOSPHATE

nh₂

ch₂-ch-cooh TRYPTOPHAM

COOH

Ć=0

ćh₃

PYRUYATE

\/ ^H2°1gLU !

GLYCERALDEHYDE-3-PHOSPHATE DEHYDRO-3-DEOXY-GLUCONATE ALDOLASE

GLUCOSE -ATP

XYLOSE

ISOMERASE

FRUCTOSE

H.O.CO.-

INDOLGLYCEROL

PHOSPHATE

SYNTHASE

COOH ,NH ^SC-H C-OH H-Ć-OH H-Ć-OH H-Ć-O-P

COOH

ę=o

H-Ć-H

H-Ć-OH

H-Ć-OH

h₂ć-o-p

P-GLUCONATE DEHYDRATASE <-

2-DEHYDRO-3-DEOXY-

6-PHOSPHOGLUCONATE

COOH

H-Ć-OH

HO-Ć-H

H-Ć-OH

H-Ć-OH

h₂ć-o-p

S-PHOSPHOGLUCONATE

LACTONASE

<-T—

GLUCOSE-S-

PHOSPHATE

DEHYDROGENASE

NADPH

6-PHOSPHOGLUCONO-

6-LACTONE

GLUCO$E-$P©',

ACETYL-CoA

GLUCOKINASE

NADP*

ATP

HEXOKINASE

ADP

1-(2-CARB0XY-

PHENYLAMIN01-

r-DE0XYRIBUL0SE-5-P

PHOSPHORIBOSYL-

AMTHRAMILATE

ISOMERASE

ANTHRANILATE-

N-RIBOSE-P

TRP

0

-PPi

ANTHRANILATE-

PHOSPHORIBOSYL-

TRAMSFERASE

• 5-P-RYBOSYL-PP

PHENYLPYRUVATE H₂0 ♦ C0₂ -

TYROSINE

IENTNER-DOUDOROFF PATHWAY

S-PHOSPHO-

GLUCOMATE

NADP*

S-PHOSPHOGLUCONATE DEHYDROGENASE NADPH.C0₂

a-KETOGLUTARATE-

TYROSINE TRANSAMINASE GLUTAMATE-

4-HYDR0XY-

PHENYLPYRUVATE

RIB0SE-5-PH0SPHATE

l_

IPENTOSE PHOSPHATE PATHWAYl

RIBOSE-P

ISOMERASE

RIBUL0SE-5-PH0SPHATE

TRANSKETOLASE

CH₂-0-P

H-Ć-OH

HO-Ć-H

Ć=0

H₂Ć-OH

XYLUL0SE-5-PH0SPHATE

_n

GLUCOSE-S-PHOSPHATE

sa phosphoglucose

'VI

ATP. PEP

p-o-h₂c

- ISOMERASE

HO H

OH

ch₂oh

GLUCOSE ^FRUCT°^^P^^PHATE HEXOSEDIPHOS- ł^_Sp_H0.

PWuTuRC    rnuarnu-

GLUCOSE-ĆP H    FRUCTOKINASE

FRUCTO$E-2.$-P.^H2⁰" v‘ADP ADP. AMP ²

FRUCT0SE-1.S-DIPH0SPHATE

MANN0SE-6-P

ISOMERASE

MANNOSE-6-

PHOSPHATE

MANNOSE h₂9-oh

H-Ć-OH H₂Ć-OH

GLYCEROL

ATP-

PREPHENATE

DEHYDRATASE

ANTHRANILATE

' - GLUTAMATE -PYRUVATE % ANTHRANILATE SYNTHASE -GLUTAMINĘ

TRP

PREPHENATE

I

. PREPHANATE X c£f^H

NAD DEHYDROGENASE /    ²

T©

TYR

H.C-OH

FRUCTOSE BISPHOSPHATE ALDOLASE

IGLYCOLYSISI

GLYCERALDEHYDE-3-PH0SPHATE NAD NADI-

SEDOHEPTULOSE-7-PHOSPHATE TRANS-UDOLASE

FRUCT0SE-1.$-P₂

GLYCEROL

KINASE

_

H₂9-OH

NADH I⁰ NAD* «2?-0H *    HO-C-H

GYLCER0L-3-P _u „ _n DEHYDROGENASE «₂C-0-P

GLYCEROL-3-

DIHYDROXYACETONE PHOSPHATE PHOSPHATE

9=0

H.Ć-OP

CHORISMATE MUTASE

CHORISMAAT

t®

TRP

t®

PHE.TYR

XYLULOSE-

5-PHOSPHATE-

TRANSKETOLASE

GLYCERALDEHYDE--3-PHOSPHATE

GLYCERALDEHYDE-3-P DEHYDROGENASE NAD* NADH

BIPHOSPHOGLYCERATE MUTASE

1.3-BISPHOSPHOGLYCERATE

*!Jp J 3-PHOSPHOGLYCERATE KINASE

90OH

H-Ć-O-P

h₂ć-o-p

COOH

Ć=0

3-PHOSPHO- T© H.Ć-O-P GLYCERATE SER DEHYDROGENASE ^PH^SPHO-

PYRUY.ATE

GLUTAMATE I a-KETOGLUTARATE -'-!-1

PHOSPHOSERINE

TRANSAMINASE

90OH

H-Ć-NH₂

h₂ć-o-p

H.O

SER

i©

3-PHOSPHO-

SERINE

PHOSPHOSERINE

PHOSPHAT.ASE

9OOH

H-Ć-NH₂

H₂Ć-OH

METHYLENE-FH

SERINE

<■

GLYCINE(SERINE)

HYDROXYMETHYL-

TRANSFERASE

GLYCINE

ACETYL-CoA-

SERINE

_CoAJ ACETYLTRANSFERASE

Pi

CHORISMATE

SYNTHASE

COOH

P-0

9^H3 O-9H

OH ĆOOH 0⁵-(1-CARB0XYVINYL)-3-P-SHIKIMATE

-Pi

3-P-SHIKIMATE-1-

CARBOXYVINYL-

TRANSFERASE

PEP

ADP

SHIKIMATE

KINASE

SHIKIMATE-5-

PHOSPHATE

900H

h-ć-nh₂

HO-Ć-H

ćh₃J

HO COOH

^HY1

O^S-^OH

OH

3-DEHYDRO-OUINATE SYNTHASE <-

3-DEHYDRO OUINATE 3-DEHYDRO-T OUINATE

DEHYDRATASE ^h2°

PHE.ALA.TYR.

PREPHENATE.

CHORISMATE

ATP

SHIKIMATE

3-DEHYDROSHIKIMATE 0 NADPH*

C.'_np*-' SHIKIMATE

NADP DEHYDROGENASE

H₂9-0-P

H-Ć-OH

H-Ć-OH

HO-Ć-H

H-Ć-H

Ć=0

ĆOOH

ERYTHROSE-

4-PHOSPHATE

_r ENZYME ) XOMPLEX^S|

7-P-DEHYDRO-3-

DEOXY-ARABINO-

HEPTONATE

90OH Ć-O-P

II

ch₂

PHOSPHOENOL-

PYRUYATE

<r

90OH

H-Ć-NH₂

ćh₃

ALANINĘ

BIPHOSPHOGLYCERATE PHOSPHATASE

3-PHOSPHOGL YCERATE    2.3-BISPHOSPHOGLYCERATE

X PHOSPHOGLYCEROMUTASE    J

90OH H-Ć-NH₂

h₂ć-o-c-ch₃

6

_Hą|_

O-ACETYLSERINE

ACETATE

-¹->

O-ACETYLSERINE (THIOL) LYASE

CYSTEINĘ

H.O

'THREONINE'

SYNTHASE

THREONINE THREONINE DEHYDRATASE NH₃

<^ILE. ATP <^AMP. ADP. VAL

90OH

H-Ć-NH₂

ćh₂

h₂c-o-p

THR. MET

< ft^TP>

HOMOSERINE KINASE

HOMOSERINE-

O-PHOSPHATE

90OH

H-Ć-NH₂

ćh₂

h₂c-oh

THR. MET

₍ NAD(P)H.j© NĄO(P)*

HOMOSERINE SUCCINYL-CoA-

HOMOSERINE. SUCCINYL-TRANSFERASE 1-CoA

MET

HOMOSERINE DEHYDROGENASE

ASPARTATE-

4-SEMIALDEHYDE

LYS

0.

2-PHOSPHOGL YCERATE

t

?2

LACT.ATE-2-M0N0 OXIGENASE ^

LACTATE

H₂0 COc

P-0-H₂C/°-. H

hOoH

OH OH

HIS

ATP J,® AMP _?

THR. LYS

I©

NftDPH iNflDP*

^C ASPARTATE ^, SEMIALDEHYDE DEHYDROGENASE

4-ASPARTYL-P

3-P-GLYCERATE^' H₂0

ENDOLASE

90OH

Ć-O-P

M

ch₂

NAD*-

LACTATE

DEHYDROGENASE

PHOSPHOENOL-

PYRUVATE~

ADP4¹ —~ FRUCT0SE-1.$-P₂

NADH-

h₂9-oh

CH',

^h2? NAD* ALANINĘ DEHYDROGENASE MĄDH NH₃

X. -Z-lT PYRUYATE KINASE •^.ATP^^-zr ALANINĘ

RIB0SE-5-PH0SPHATE

FROM PENTOSE PHOSPHATE PATHWAY

RIBOSE-P-PYRO-

PHOSPHOKINASE

P-O-H-

H ^-P-n-1

OH OH

ATP

5-RIBOSYL-PP

ATP PHOSPHORIBOSYL TRANSFERASE

-PPi

a-KETOGLUTARATE

ALANINĘ GLUTAMATE TRANSAMINASE    ^c-°²

ASPARAGINE

ACETYL-CoA, ^ ATP. NADH -S.

PEP-

COOH

Ć=0

ćh₃

ETHANOL

NAO*T.ALCOHOL NADH DEHYDROGENASE

PYRUV.ATE _H r-n ALDEHYDE DECARBOXYLASE.    DEHYDROGENASE

T=T—7 ch₃

PYRUVATE^ DEHYDROGENASE

PYRUYATE

CoA ♦ NAD*-1 PYRUV.ATE CO. .NADH ŁDEHYDROGENASE CQMFLEX

COOH

ĆH₃

ACETATE

h₂0-

ASPARAGINASE

NH₃-1

THR. LYS. MET ,ĄOF-|vATP 'ASPARTATE ⁷ KINASE

«-KETOGLUTARATE GLUTAMATE ASPARTATE TRANSAMINASE

ASPARTATE

■AMP

ASPARTATE

AMMONIA-

LYASE^rASN ■ATP ^ «-KETO-”NH-> GLUTARATE.

SUCCINATEJ0

PYRUYATE

CARBOXYLASE

CITRATE

SYNTHASE

P-0-H29/0-..H	nh2
	^h§yV
OH OH l
P-O-H.C	/°\l
H^	«U/0H
	ÓH OH

PHOSPHORIBOSYL-

FORMIMINO-AICAR-P

[-GLUTAMINĘ

PHOSPHO-RIBOSYL-HąO AMP PPi

<-

PHOSPHO-

RIBOSYL-

AMP-

CYCLO-

HYDROLASE

»2Q

0

P-O-H.C    H NH^

**    .^N

PHOSPHO-

RIBOSYL-

ATP-

PYROPHOS

PHATASE

L>

P-O-P-O-P-O-H.C/0

N^ N

OH OH

OH

PHOSPHORIBOSYL-ATP

OXALOACETATE NADH,

DEHYDE ^NA°P* NADPH

NAD* NADH

CITRATE LYASE

ATP-t©

ACETYL-CoA^CITRATE ^0 LYASE ' [FRUCTOSE. GLYCEROL

CITRATE

cis-ACONITATE

fvH₂0

■Jr GLUTAMATE ♦ AICAR

H₂9-0-P

H-Ć-OH

H-Ć-OH

H.O

IMIDA20LE-

GLYCEROL-P

DEHYDRATASE

H₂9-0-P H-Ć=0 H₂Ć

&

ot-KETOGLUTARATE . GLUTAMATE I .

HISTIDINOL-P

TRANSAMINASE

h₂9-0-P

h-ć-nh₂

t>

ii

H.O

HISTIDINOL-P

PHOSPHAT.ASE

H₂9-OH

h-ć-nh₂

t>

ii

2 NAD* 2 NADH

4->-»

HISTIDINOL

DEHYDROGENASE

90OH

H-Ć-NH₂

t>

ii

ICITRIC ACID CYCLEI

PYRUVATE

■PYRUVATE

ACETOHYDROXY ACID SYNTHETASE

VAL

2-0X0-BUTYRATE PYRUYATE •

COOH	COOH
H-Ć-NHo	?^H2
h29	?»2
h2c-0	-c=o

[-PYRUVATE

D1HYDR0DIPIC0LINATE SYNTHASE •2H₂0

CITRATE

ATP

MALATE / DEHYDRO-/ GENASE / NAD*-

\ ACONITASE

O-SUCCINYL-HOMOSERINE O-SUCCINYL- [-CYSTEINE HOMOSERINE (THIOL)-LY.ASE 1-SUCCINATE

2.3-DIHYDRODIPICOLINATE

PHOSPHOENOL-MALATE PYRUYATE SYNTHASE    -i©

T

MALATE

O H

V

COOH

MALATE.

SUCCINATE. PHOSPHOENOL-PYRUYATE

ISOCITRATE , LYASE

1°

ACETYL-CoA

♦h₂o glyoxylate

IGLYOXYLATE CYCLEI

BIOSYT/THESES ENERGY I

COOH

ćh₂

H-9-COOH HO-Ć-H ĆOOH

GENERATIONi ISOCITRATE

ERYTHRO-

IMIDA20LE-

GLYCEROL-

PHOSPHATE

IMIDA20LE

ACETOLPHOSPHATE

HISTIDINOL-

PHOSPHATE

HISTIDINOL

HISTIDINE

GLUTAMINĘ

. s .

2-ACETO-

LACTATE

-NADPH

LEU 2-ACETO-2-HYDROXY-VAL BUTYRATE

ILE

I⁰

REDUCTOISOMERASE

NADPH-

90OH

H-Ć-NH₂ 900H ćh₂ h-ć-nh₂ ćh₂-s-ćh₂

-NADPH

DIHYDRODIPICOLINATE

REDUCTASE

-NADP*

FUMARASE\

ATP ADP

CYSTATHIONINE

CYSTATHIONINE ’^H2° A-LYASE -NH₃

•PYRUYATE

ASPARTATE NH₃ AMMO NI A-L Y ASE

9OOH

ĆH₂

ĆOOH

J ;f'JADP* 90OH H-Ć-OH

ch₃-ć-oh

ćh₃

2.3-DIHYDROXY-

ISOY.ALERATE

NADP*-,

90OH

H-Ć-OH

ch₃-ch₂-ć-oh

ćh₃

2.3-DIHYDROXY-

3-METHYLYALERATE

90OH

H-Ć-NH₂

ćh₂

9^H2

SH

PIPERIDEINE-2.S-

DICARBOXYLATE

■H₂0

■ SUCCINYL-CoA ■CoA

|h₂

ACETYL-CoA V-

COOH

ć=o ch₃-ć-h

ch.

DIHYDROXY ACID DEHYDRASE

2-OXO-3-METHYL-

YALERATE

HOMOCYSTEINE 5-METYL-THF-5-METHYL-THF-HOMOCYSTEINE ,© METHYL TRANSFERASE THF-I

MET

9OOH

H-Ć-NH—C=0

(Ćh₂)₃ Ćh₂ 9=0 9h₂

ĆOOH ĆOOH

SUCCINYL-2-AMIN0-

6-0X0PIMELATE

2-0X0IS0-

YALERATE

-GLUTAMATE-

BRANCHED-CHAIN-AMINO ACID TRANSAMINASE - o:-KET OGLUT ARATE —

YALINE

900H h-ć-nh₂ ch₃-ch₂-ć-h

ćh₃

GLUTAMATE o:-KETOGLUTARATE I 4-1-—-2—

LEUCINE

ISOLEUCINE

IBRANCHEO AMINO ACIDŚ1

LEU 0 4. CoA

2-ISOPROPYL-

MALATE

SYNTHASE

3-ISOPROPYL-

MALATE

DEHYDRATASE

3-CARB0XY-

3-HYDR0XY-

ISOCAPROATE

COOH

Ć-H

Ć-COOH

CH₃-9-H ĆH.

9OOH

h-ć-nh₂

ćh₂

9^H2

s-ch₃

METHIONINE

BRANCHED-CHAIN-AMINO ACID

TRANSAMINASE ₂__0X0|SQ.

CAPROATE

3-ISOPROPYLMALATE

DEHYDROGENASE

LEU 0-yLNAD

COOH

h₂o ^leV⁰    h-?'^oh

3-ISOPROPYL-

MALATE

DEHYDRATASE

DIMETHYL-

CITRACONATE

H-9-COOH

CH₃-Ć-H

ćh₃

3-ISOPROPYŁ

MALATE

[-GLUTAMATE SUCCINYL-DIAMINO-PIMELATE TRANSAMINASE o;-KETOGLUT ARATE

90OH

H-Ć-NH—C=0

(Ćh₂)₃ Ćh₂ h₂n-9-h    9h₂

ĆOOH ĆOOH

SUCCINYL-LL-2.6-DIAMINOPIMELATE -H₂0

SUCCINYL-DIAMINO-PIMELATE DESUCCINYLASE .[-SUCCINATE

9OOH

h-ć-nh₂

(ĆH₂)₃

h₂c-nh₂

DIAMINOPIMELATE

DECARBOXYLASE

9OOH

H-Ć-NH₂

(ĆH₂)₃

h-9-nh₂

ĆOOH

90OH

H-Ć-NH₂

(ĆH₂)₃

H.N-C-H

DIAMINOPIMELATE EPIMERASE

COOH LL-2.6-DIAMINO-PIMELATE

meso-2.S- DIAMINO-PIMELATE

I

BACTERIAL CELL WALLS

I

BACTERIAL CELL WALLS

ADP- -H₂0 GLUTAMATE

AMMONIA GLUTAMINASE

© ^NAD* ■^/ISOCITRATE ./DEHYDRO-©7 GENASE A NADH +C0₂

GLU.

GLYCEROL

LIGASE

NHj.ATP^ ^NH₃

COOH

ćh₂

9^H2

9=0

ĆOOH

_flH NADPH 13 NADH

MALONATE.

OXALO-ACETATE

FUM ARATE I-

fadh₂łP ?ooh

SUCCINATE >>

DEHYDROGENASE I

FAD COOH    -_ . _ _x -- - — -

PORPHYRINS ^- SUCCINATE qj_P gpp SUCCINYL-CoA NADH+C0₂

SUCCINYL-CoA

SYNTHETASE

atp©

a-KETOGLUTARATE

⁰L^NAD*

a-KETOGLUTARATE ^ \ DEHYDROGENASE \ COMPLEX

SUCCINYL-CoA f- NADH

NADP* NAD* h₂0.

GLUTAMATE DEHYDROGENASE

GLUTAMATE

KINASE

ATP ADP

9OOH

H-Ć-NH₂

ćh₂

9^H2

o=c-o-p

PYRROLINE-2-

CARBOXYLATE

REDUCTASE

GLUT.AMATE-5-SEMIALDEHYDE DEHYDROGENASE <—^^^ NADPH NADP*

GLUT.AMATE-5-

SEMIALDEHYDE

1-PYRROLINE

5-CARB0XYLATE

ATP. ADP

PROLINE

C0₂ ATP _1_

ADP

_Ł_

COOH

ćh₂

9=0

Ś-CoA

ACETYL-CoA ACETYL-CoA CARBOXYLASE MALONYL-CoA

acp4acetyl

TRANSACYLASE

CoA^

R-COOH FATTY ACID CoA.ATP 4' ACYL-CoA PPi.AMP i SYNTHETASE

GLUTAMATE

-ACETYL-CoA AMINOACID ACETYLTRANSFERASE ,;CoA 9OOH

h-ć-nh-co-ch₃ ćh₂

?«2

COOH

GLUTAMYL-P

N-ACYL-GLUTAMATE ^ KINASE

ATP?© ADP

ARG

90OH

H-Ć-NH-CO-CH₃

ćh₂

9^H2

0=C-0-P

N-ACETYL-

GLUTAMYL-P

.REDUCTASE^

^ NADPH 1    \

0|NADP

90OH

H-Ć-NH-CO-CH₃

ćh₂

9^H2

0=C-H

ACEP7L-ORNITHINE TRANSAMINASE i-7-r->

GLUTAMATE a-KETOGLETT ARATE

9OOH

h-ć-nh-co-ch₃ ćh₂ 9^H2

0=C-0-P

acp4'malonyl

CoA^traws.ACYLASE

R-CH.-CH.-CH.-C-S-CoA

N-ACETYL-GLUTAMATE N-ACETYL-GLUTAMYL-P Arg

IFATTY ACIDI SYNTHESIS

COOH

ćh₂

9=0

Ś-ACP

ACYL-ACP

MALONYL-ACP -

ACP . CO. ACYL-MALONYL-ACP CONDENSING ENZYME

O o

h^.c-ć-ch₂-ć-s-acp

... _npw ACETOACETYL-ACP NADP*—B-KETOACYL-ACP REDUCTASE

3-HYDR0XYBUTYRYL-ACP

3-HYDR0XYACYL-ACP

HoO-

DEHYDRATASE

CROTONYL-ACP

^ADP*! EWOYL-ACP REDUCTASE

H.C-CH.-CH.-C-S-ACP

H29

ACYL-CoA FAD-J ACYL-CoA F.ADH24, DEHYDROGENASE H O

R-CH₂-9=Ć-Ć-S-CoA “ H

ENOYL-CoA

H₂ot ENOYL-CoA HYDRAT ASE l (CROTONASE)

HYDROXY ACYL-CoA NAD* 4' 3-HYDR0XYACYL-CoA NADHŁ DEHYDROGENASE

O O

R-CH₂-Ć-CH₂-Ć-S-CoA

KETOACYL-CoA

ft-KETOTHIOLASE

(THIOLASE)

?»3

9=0

Ś-CoA

IFATTY ACIDI OXIDATION

R

ĆH₂

9=0

Ś-CoA

N-ACETYL-

GLUTAMATE

SEMIALDEHYDE

ACETYLORNITHINE OEACETYLASE ,

ACETATE*

N-ACETYLORNITHINE

ORNITHINE

CARBAMATE

KINASE

UREASE t©

_NH₃

IUREA CYCLEI

ARGININE

ARG

CARBAMOYL-P '*‘ADP.H₂0 ATP

ORNITHINE CARBAMOYL-TRANSFERASE

©

» 2NH₄*

CITRULLINE

ARG^ ARGININÓ-SUCCINATE LYASE

COOH HĆ CH

ĆOOH

FUMARATE

COOH
H-C-NH	2
?»2
?»2
CH0
1 ^CHN	H COOH
'C-	N-Ć-H
HN^	ćh2
	COOH

ARGININO-

SUCCINATE

ARGININO-SUCCINATE SYNTHETASE

ATRJ

AMP.

ASPARTATE

BUTYRYL-ACP

OLEYL-ACP

HYDROLASE

R-COOH FATTY ACID

ACETYL-CoA

ACYL-CoA SHORTED BY TWO CARBON ATOMS