F00574 020 f018

Sympathetic nervous system

Sympathetic nervous system

I

Adrenalinę Noradrenalinę (Epinephrine) (Norepinephrine)

II_

3-adrenoceptor a-adrenoceptor

Vasodilatation Vasoconstriction Tachycardia Insulin resistance

Adrenal medulla

Hypothalamic-pituitary-adrenal axis

Adrenal cortex Zonae fasciculata and reticularis

Negative feedback

ACTH

1

3-LPH

i

Pigmentation

Cortex

Zonae fasciculata and reticularis

i Androgens I	1 1 • X i Cortisol I I :
▼ Androgen	▼ Glucocorticoid
receptor 1	receptor I
▼ Hair (e.g. pubie	▼ Metabolic regulation
and axillary)	(e.g. protein catabolism;
Libido (esp. in	insulin resistance)
females)	Immunomodula tion Cardiovascular regulation (e.g. raised blood pressure) CNS actions (e.g. increased appetite; impaired memory)

Adrenal cortex Zona glomerulosa

Renin-angiotensin-aldosterone axis

Angiotensinogen ♦CRenin'

r

Increased blood pressure Na retention K wasting Metabolic alkalosis

t

Angiotensin I

Angiotensin II Cortex

Zona glomerulosa

i

Aldosterone

J

© Elsevier. Boon et al.: Davidson's Principles and Practice of Medicine 20e - www.studentconsult.com