Fig 2
5J00
|
450 | |
|
4 J00 | |
|
£ u |
350 |
|
.5 | |
|
U |
3 DO |
|
O |
250 |
|
> | |
|
3 |
2D0 |
|
O |
150 |
|
H |
IDO |
|
050 | |
|
ODO |
contr ol
vehicle control
cyclophosphatnide
(lOmgfmę
RNRAj^Omgfml)
RNRA(100mg^mę
RNRA(50mgfml)
Iititial llth 14th 17th 20tk 23th 26łh 29th 32th 35th 38tłi
Number ofdays
FIG. 2: Effect of R.niveus on solid tumor development is shown in the graph. A dose-dependent decrease in the tumor volume was observed; the untreated and vehicle treated groups showed 4.06 and 3.85 cm3 tumor volume on day 38, which was significantly higher than that of the standard cyclophosphamide 10 mg/ml (1.01 cm3) 250, 100, and 50 mg/kg RNRAextract treated groups (2.07, 2.46, and 2.89 cm3, respectively).
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