Table 7-2 Characteristics of Some Humań Liver P450s
Gene |
Enzyme |
Substrates |
CYP1A2 |
P450IA2 |
Acetaminophen, caffeine, theophylline |
CYP2C |
P450IIC* |
Mephenytoin, hexobarbital, diazepam, tobultamide, sulfinpyrazone, phenylbutazone |
CYP2D6 |
P450IID6 |
Debrisoquine, dextromethorphan, metoprolol, other beta blockers, perhexiline, amitriptyline. other neuroleptics, encainide, flecainide, codeine |
CYP2F1 |
P450IIE1 |
Acetaminophen, ethanol |
CYP3A4 |
P450IIIA4 |
Erythromycin, cyclosporine, steroids, estrogens, midazolam/triazolam, nifedipine, diltiazem, lidocaine, triacetyloleandomycin (TAO), ketoconazole, miconazole, quinidine, lovastatin, FK506 |