100649

100649



Table 7-2 Characteristics of Some Humań Liver P450s

Gene

Enzyme

Substrates

CYP1A2

P450IA2

Acetaminophen, caffeine, theophylline

CYP2C

P450IIC*

Mephenytoin, hexobarbital, diazepam, tobultamide, sulfinpyrazone, phenylbutazone

CYP2D6

P450IID6

Debrisoquine, dextromethorphan, metoprolol, other beta blockers, perhexiline, amitriptyline. other neuroleptics, encainide, flecainide, codeine

CYP2F1

P450IIE1

Acetaminophen, ethanol

CYP3A4

P450IIIA4

Erythromycin, cyclosporine, steroids, estrogens, midazolam/triazolam, nifedipine, diltiazem, lidocaine, triacetyloleandomycin (TAO), ketoconazole, miconazole, quinidine, lovastatin, FK506


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