2 clean

ch₃

ooc—ch₂ —c—ch₂—ch₂—oh

12    31    4    5

ÓH

Mevalonate

ADP

jh₃    o

ooc—ch₂ —c—ch₂—ch., —O—P—O-

i

5-Phosphomevalonate

ADP

ch₃ !

O

O

OOC—CH₂—C—CH₂—CH₂—O—P—O—P—O’

I    I    I

OH    O    O

5-Pyrophosphomevalonate

OOC—C

Activated

isoprenes

pyrophospho-

mevalonate

CH

ATP

^V-> ADP

O

O

:h₉—ć—ch₂ —ch₂—o—f>—o—p—o

o    0“ o^-

6—p—o

i-

3-Phospho-5-

pyrophosphomevalonate

pyrophospho . mevalonat« ^    M

f^Ha V V

ch₂ =c—ch₂—ch₂—o—p—o—p—o

I

o

AMsopentenyl pyrophosphate

CH₃

O

O

I    Jl

CH₃—C=CH—CH₂—O—P—O—P—O ■

o^- A~

Dimethylallyl pyrophosphate

FIGURĘ 21-35 Conversion of mcvalonato to activatcd isoprcnc units.