NLs

NLs



Transport to the nucleus (NLS) -Pro-Pro-Lys-Lys-Lys-Arg-Lys-Val-

Transport to the endoplasmic reticulum H2N-Met-Met-Ser-Phe-Val-Ser-Leu- Leu-Leu-Val-Gly-lle-Leu-Phe-Trp-Ala-Thr-Glu-Ala-Glu-GIn- Leu-Thr-Lys-Cys-Glu-Val-Phe- Gln-Retention to the endoplasmic reticulum -Lys-Asp-Glu-Leu-COOH

Transport to the mitochondrial matrix H2N-Met-Leu-Ser-Leu-Arg-Gln-Ser- lle-Arg-Phe-Phe-Lys-Pro-Ala- Thr-

Arg-Thr-Le u-Cys-Se r-Se r- Arg-Tyr-Le u-Le u-

Transport to the peroxisome (PTS1) -Ser-Lys-Leu-COOH

Transoort to the oeroxisome (PTS2) H.N-----Are-Leu-X.-His-Leu-    ____

Humań influenza    4

virus A    Met Lys Ala Lys Lcu Lcu Val Lcu Leu 1Vr Ab Phc Val Ala Gly Asp Gb —

Humań    +

preproinsulin Met Ab Leu Trp Met Arg Leu Lcu Pro Lcu Lcu Ala Lcu Leu Ab Leu Trp Gly Pro Asp Pro Ala Ala Ab Phc Val —

Bovine

growth

normone


Met Met Ala Ala Gly Pro Arg Tłu- Ser Leu Leu Leu Ab Phe Ab Leu Leu Cya Leu Pro Trp Hu- Gin Val Val Gly Ab Phe —

Bee

promellitin


Met Lys Phe Leu Val Asn Val Ab Leu Val Phe Met Val Val Tyr He Ser Tyr Ile Tyr


Ala Ala Pro —


Drosophila glue    +

protein    Met Lys Lcu Leu Val Val Ab Val Ib Ab Cya Met Leu Ile Gly Phe Ab Asp Pro Ab Ser Gly Cya Lys —

FIGURĘ 27-37 Amino-terminal signal sequences of some eukaryotic    the polar and short-side-chain residues immediately preceding (to the

proteins that direct their translocation into the ER. The hydrophobic    left of, as shown here) the cleavage sites (indicated by red arrows).

core (yellow) is preceded by one or morę basie residues (bluej. Notę

Sekwencje sygnałowe mają długość od 13 do 36 reszt aminokwasowych, o następujących cechach:

(1)    około 10 do 15 hydrofobowych aminokwasów,

(2)    jedną lub więcej dodatnio naładowanych reszt, zazwyczaj w pobliżu N-końca, poprzedzającą hydrofobową sekwencję, oraz

(3)    krótka sekwencja na końcu karboksylowym (w pobliżu miejsca cięcia), która jest stosunkowo polarna, mająca zwykle reszty aminokwasowe o krótkich łańcuchach bocznych (zwłaszcza Ala) w pozycjach najbliższych do miejsca cięcia.


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