IMGP4963

Li-Fraumeni syndrome (criteria)

Proband affected by sarcoma, brain tumor, breast \ cancer, or adrcnocortical carcinoma (ACC) <36 ycars of age with a) at least one first- or second-degree relative with cancer (other than breast cancer if the proband bas breast cancer) <46 years of age or b) a relative with multiple primary tumors at any age.

Proband with multiple primary tumors, two of which are sarcoma, brain tumor, breast cancer, and/orACC, with the initial cancer occurring <36 ycars of age, regardless of family history.

Proband with ACC regardless of age of onset or family history.