IMG48 (5)

A Altoration in gono slructuro *n inhontod psychiatrie dicoaso

B Altorniion In pnt rogulauon in

acquiiitp^MćdiSiasQ

Normal gen©

Enhancer    P>omolvr CocJing reg,on

[Transcnptron

P

^7!50Q^37^^l 'ffeus

\ Pr    j /tóAAft

\--■    mRNA

Regulatory

protein

MN \

(iiiIymrriKł'

itansfation

Gcno is not expressed gnhnnccr

Regulatory

protein

Promotor CoOngragion

2iWiś^:Wf-i^r')

Protom

RNA

potymornso

2 Mutation

2 Gen© ts expressod

^L<jC

Tim

jAlcftlolT fc^kj V y jTransci :puon

/WVAA mRNA | Trsns^Hon

‘fflfe

Protom

ItTcUii lejo i a}

| Transcripsian /WAAAA mRNA i Transłotion

Protom

'cAMP-Otp«nd»nt protom krna&o

O-HT — CAMP

t

Learning

J