83312 IMGP4959

Wilms’ tumour

* The deveiopment of Wilms' tumour u comples and is likely to

invohc set cml other gcnctic locL A number of other genes-oa-----

chrom o to me lip have abp been impllcatcd in Wilms* tumour, induding the putathe WT2 genc (llplS).

• Other chromosomal region* associatcd witfa WT indudc 7p, j I lp!5, 16q and 17q. Although many of thcsc Iod probably contd tumour suppressor genes, imprinted genes (genes showing    1

espression of onl>' one pa ren tal alicie) and oneogenes havc also I been im p lica ted in WT. Some Ioci have been showń to be associated witb particular dinical outeomes, suggesting that thfl mighl be used to determine prognosis, and especially to identif poor prognostic subgroups that can be targeted for aggrcsshc and/or novel the rapie*.