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Few countries have effectively used testing to control the spread of the virus. A scalable antibody test is likely to be an important tool in managing the pandemie

As of 10^ May

Total number of tests    Tests in the past week *

Tests per thousand peopie    Tests per thousand people

When to use which SARS-CoV-2 diagnostic test?**

Countries that pioneered testing early, such as South Korea. have reduced their testing volumes as they have obtained greater control ofthe spread ofthe virus, while others, such as Italy and the U.K., have inereased testing significantly in recent weeks

r-1 Is the sickness	RT-PCR tests
COVID-
19? l j	Antigen tests
r ^ How is the immune system reacting to virus? L_J	Anti body tests

Reverse transcription polymerase chain reaction (RT-PCR) tests, done on viral genetic materiał, require laboratory environment

Capacity extension at short-notice is not possible and there are concerns over shortages of reagents required for the test

Antigen tests are a quick way to look for the virus but require a large amount of virus for accurate results

Current level of accuracy ranges from 34%-80% (WHO)

Antibody tests are used to determine if a person has developed antibodies against a pathogen, and may therefore be immune

Roche CON/ID-19 antibody test received FDA Emergency Use Authorisation and can be carried out on Roche Systems

1    i

| Limited !

2    scalability 2

i_________•

\ Accurate ! J on those 2 ; infected )

2 Accuracy [ likely too Iow

/

High

priority to 2 scalę )

Likely to j be used j alongside ; RT-PCR ;

Notę:    * Pasł week represents either April 27* to May 5* or April 28* to May 6* depending on data availability ** non laboratory tests. such as point ot care lateral flow tests are also being pursued, but to datę have not proved either

accurate enough or specific enough to be of use Source: Roche; Our World in Data; L.E.K. research and analysis 7