3513659351
VI
Figurę supplementaire (Chapitre 1) 2. The relative proportions of the pro- and maturę forms
of furin are not altered by hypoxia.....................................................................................105
Figurę supplementaire (Chapitre I) 3. In vivo localization of furin in tumor xenografts .. 106 Figurę supplementaire (Chapitre 1) 4. CK-II is involved in furin relocalization in hypoxic cells.....................................................................................................................................107
CHAPITRE 2 :
Figurę (Chapitre 2) 1: La neutralisation du pH intracellulaire inhibe la maturation du TGFp
............................................................................................................................................115
Figurę (Chapitre 2) 2. Conservation des histidines dans le site de clivagc proteolytique
Figurę (Chapitre 2) 3. La maturation du TGFp est dependante de la protonation des
Figurę (Chapitre 2) 4. La basification des compartiments intracellulaires affecte la
Figurę (Chapitre 2) 5. La relocalisation deficientc de la furine a la peripherie cellulaire
Figurę (Chapitre 2) 6. La maturation du TGFp dependante du pH influence la capacite des
Figurę (Chapitre 2) 7: Schematisation de la proble'matiquc de notre modele d etude en
Figurę (Chapitre 2) 8: L'hypoxie induit racidification des vesicules intracellulaires........129
CHAPITRE 3 :
Figurę (Chapitre 3) 2. Endogenous TGFp is involvcd in hypoxia-induced invadopodia
Figurę (Chapitre 3) 3. The Smad3-dependent signalling pathway is involved in hypoxia-
Figurę (Chapitre 3)4. FIDAC6 is invo!ved in hypoxia-induced invadopodia formation... 157
Figurę (Chapitre 3) 5. FIypoxia induccs HDAC6 deacetylase activity...............................158
Figurę (Chapitre 3) 6. The EGF/EGFR signalling pathway is involved in hypoxia-induced
Figurę supplementaire (Chapitre 3) 1: Hypoxia induces the phosphorylation of Smad3... 168 Figurę supplementaire (Chapitre 3) 2. Hypoxia does not cause p-Smad2 nuclear
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