4613347702

Recently, our group has characterized various VSV glycoprotein (G) mutants (Janelle et al., 2011). G mutants interfere with host celi metabolism by inhibiting cellular transcription and translation in a kinetic similar to the WT virus as opposed to the prototypie matrix (M) mutant (Mmsir) that is slightly attenuated in vitro (Janelle et al., 2011). G mutants proved to be especially cytolytic for B16 melanoma cells. One such mutant (Gór) also maintains the ability to induce type-I interferon in non-cancerous celi lines at levels similar to the Mmsir mutant suggesting that it could be a safe and potentially morę effective altemative to Mmsir. Furthermore, G mutants can still induce the translocation of calreticulin at the celi membranę

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