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Figurę 1: Charactenstics of VSV mfections m B16 melanoma tu mors. (a) C57B1/6 mice (n=3 mice per group per time point) were injected subcutaneously with B16 cells and infected with a single intratumoral dose of either VSV WT or the mutants with 5xl0⁸ PFU on day 7, harvested right after injection and on indicated days post-infection. Virus titers were assayed using standard plaąue assay. Data are the mean ± SEM of three tumors. (b) C57B1/6 mice (n=6) were injected subcutaneously with B16 cells and infected locally at tumor site with 5.0 x 10⁸ PFU of WT or mutant VSV on day 7, 9 and 11. Sera from the indicated days after infection were tested for total neutralizing immunoglobulins and IgGs using a plaąue reduction assay. Indicated data points represent serum dilutions that reduced plaąue formation by 50%. Data represent the mean ± SEM of three independent experiments.