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Figurę 6: Expression of PD-1 and PD-L1 on BI6gp33 cells following VSV infection.
B16gp33 cells were infected at an MOI of 10 or mock-infected. At 24 hours post-infection, cells were labeled to measure (a) PD-1 and (d) PD-L1 expression by flow cytometry. Data are the mean ± SEM and representative of two independent experiments in triplicates B16gp33-bearing mice (n= 6-9) were also infected locally at the tumor site with 5.0 x 108 PFU of WT or mutant VSV on day 7, 9 and 11 and treated either with (b,c) anti-PD-1 (250pg), (e,f) anti-PD-Ll (200pg) or isotype control antibodies on day 6, 10 and 14. On day 8 following the first VSV dose, splenocytes were isolated and stimulated ex vivo with VSV-N (RGYVYQGL) or gp33 (KAVYNFATC) peptides to analyze cytokines secretion. Data show the combination of three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001.
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